Medizinische Fakultät: Auflistung Medizinische Fakultät nach Klassifikation (DDC) "ddc:500"
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Blutungsbedingte Nebenwirkungen der Therapie des Blepharospasmus und Hemispasmus facialis mit Botulinumneurotoxin unter antithrombotischer Medikation
Wenninger, Fiona Carolin (2024-03-04)Ziel der Studie war es die Häufigkeit und Tragweite blutungsbedingter Nebenwirkungen der Behandlung des benignen essentiellen Blepharospasmus (BEB) und Hemispasmus facilais (HFS) mit Botulinumneurotoxin A (BoNT/A) unter ... -
Control of pulmonary immunity by physical exercise
Michla, Marcel (2024-03-06)Sedentary lifestyles combined with high caloric nutrition are widely known to severely contribute to the rise of metabolic diseases like diabetes, atherosclerosis, or obesity in recent years. While endurance training has ... -
The Effects of Orciprenaline on the Contractility of Isolated Cardiomyocytes under Septic Conditions Mediated by Lipopolysaccharide
Seo, Joon Young (2018-07-06)The septic cardiomyopathy is associated with a high morbidity and mortality. In a sepsis, the contractility of a cardiomyocyte is reduced significantly. Consecutively, the cardiac output of the heart is compromised. This ... -
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
Mann, Marcel (2023-03-23)Einleitung: Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ... -
Endocannabinoid system and the aging locus coeruleus
Gargano, Alessandra (2022-11-28)The locus coeruleus (LC) is a small nucleus located in the pons of the brainstem, representing the major source of noradrenaline (NE) in the central nervous system. Although the LC consists of a relatively low number of ... -
Entwicklung und Evaluation einer quantitativen „one-step“ RT-PCR zur Bestimmung von CD103 im Urin
Weiß, Christiane (2008)Bei unklarer Genese einer Funktionseinschränkung von Nierentransplantaten wird meist eine Biopsie durchgeführt, die bis heute als diagnostischer Goldstandard gilt. Um die mit einer Biopsie verbundenen Risiken zu vermeiden, ...
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Functional and cellular heterogeneity of the myeloid cell system
Günther, Patrick (2020-11-09)Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ... -
Immune defense mechanisms against Legionella longbeachae
Scheiding, Victoria Madeleine (2020-01-30)The pulmonary epithelial barrier is the first line of defense against pathogens invading the lungs. If those are able to overcome this first barrier, myeloid cells of the innate immune system are instrumental for the ... -
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Friker, Lea Lydia Magdalena (2021-10-26)Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ... -
Impact of chronic liver inflammation on adaptive immune responses to viral infection
Assmus, Lisa Mareike (2020-03-11)A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ... -
Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
Valencia Hernandez, Ana Maria (2020-12-16)Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ... -
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
Schwab, Lara Sonja Ute (2022-05-17)Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ... -
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
Schmidt, Henrik Johannes (2021-07-15)The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ... -
Mechanisms underlying the effects of context on food decisions in humans
Rramani Dervishi, Qëndresa (2023-05-25)Food decisions are inevitable, frequent, and complex decisions with a high impact on our health. Understanding the mechanisms that underly food decisions has become a multidisciplinary endeavor over the last decades, ... -
Modulation der antibakteriellen Immunantwort in Blut und Aszites durch von Immunzellen produzierten Katecholamine bei Patienten mit Leberzirrhose
Nischalke, Christina (2024-01-05)Hintergrund und Ziele: Der Verlauf einer Leberzirrhose mit Aszites kann durch verschiedenste Parameter beeinflusst werden. Im Rahmen der vorliegenden Arbeit wurde untersucht, ob Immunzellen im Blut und / ... -
Participation of Ste20-like kinase-deficient neurons in the abnormal circuitry of focal epileptogenic lesions
Royero Rodriguez, Pedro Xavier (2022-01-03)Focal epileptogenic lesions displaying morphologically altered neurons are frequently associated with devastating and therapy-refractory epilepsies. However, it is still unsolved how dysplastic neurons contribute to the ... -
Physical activity and fitness for healthy ageing
Fox, Fabienne Andrea Ulrike (2024-02-19)The proportion of individuals suffering from age-associated noncommunicable diseases is expected to rise rapidly in the next decades. To maintain health, well-being and socioeconomic stability in an ageing society, identifying ... -
Platelets shape the immune response of primary human monocytes
Hawwari, Ibrahim (2023-01-13)Monocytes are circulating immune cells essential to host defense, orchestrating immune responses through the secretion of immunomodulatory mediators. While exuberant monocyte-driven immune responses have life-threatening ... -
Retrospektive Kohortenanalyse fortgeschrittener HNO-Tumore am Universitätsklinikum Bonn
Grote, Sarina (2019-11-13)Kopf-Hals-Tumore stellen weltweit eine führende Rolle in der tumorbedingten Sterblichkeit dar. Kopf-Hals-Tumore sind eine sehr heterogene Gruppe von Tumorentitäten. Gesamtzahlen beziehen sich meist auf Schätzungen oder auf ... -
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
Zhao, Wenchao (2020-11-04)Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...