The Faculty of Medicine: Medizinische Fakultät: Recent submissions
Now showing items 1021-1040 of 2414
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Loneliness: Cognitive factors and neurobiological mechanisms
(2023-05-10)Loneliness is a painful condition with detrimental effects on physical and mental health. However, it is still unclear which mechanisms hinder lonely individuals from forming new social relationships which might alleviate ... -
Targeting Oncogenic RAS Signaling in Pancreatic Cancer: Interaction of small molecular inhibitors in the presence and absence of irradiation
(2023-05-08)Pancreatic ductal adenocarcinomas account for 80−90% of all pancreatic malignancies and are among the most lethal of cancers known to date. They are driven by oncogenic KRAS mutations in over 90% of cases, which have been ... -
Parameters Associated with the Required Drug Dose of Intravenous Immunoglobulin in Stable Chronic Inflammatory Demyelinating Polyradiculoneuropathy
(2023-03-10)Background: Intravenous immunoglobulin (IVIg) is efficient and one of very few treatment options for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, finding the optimal dose of ... -
Evaluations of the Authenticity of News Media Articles and Variables of Xenophobia in a German Sample: Measuring Out-Group Stereotypes Indirectly
(2023-03-11)Xenophobic and right-wing attitudes have become a major issue in Western societies. The present study investigated how such attitudes and stereotypes influence media perception in terms of identifying manipulated news ... -
Delphi study for the development and preliminary validation of an item set for the assessment of non-experts’ AI literacy
(2023-01-12)Artificial intelligence literacy is a concept that has been the focus of exhaustive research recently. However, there are very few psychometrically sound and thoroughly evaluated instruments that attempt to assess AI ... -
Second-line and third-line therapy with nanoliposomal irinotecan (nal-IRI) in pancreatic cancer: a single-center experience and review of literature
(2023-02-15)Background: Prognosis of patients with pancreatic cancer is still extremely poor. First-line palliative therapies with FOLFIRINOX or gemcitabine/nab-paclitaxel have been established in the last decade. In the second-line, ... -
X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems
(2022-11-15)Background: SHROOM4 is thought to play an important role in cytoskeletal modification and development of the early nervous system. Previously, single-nucleotide variants (SNVs) or copy number variations (CNVs) in SHROOM4 ... -
Virtual reality in the diagnostic and therapy for mental disorders: A systematic review
(2022-10-30)Background: Virtual reality (VR) technologies are playing an increasingly important role in the diagnostics and treatment of mental disorders. Objective: To systematically review the current evidence regarding the use ... -
Effects of Different Titanium Surface Treatments on Adhesion, Proliferation and Differentiation of Bone Cells: An In Vitro Study
(2022-09-05)The objective of this study was to evaluate the impacts of different sandblasting procedures in acid etching of Ti6Al4V surfaces on osteoblast cell behavior, regarding various physicochemical and topographical parameters. ... -
Neural Correlates of Smooth Pursuit Eye Movements in Schizotypy and Recent Onset Psychosis: A Multivariate Pattern Classification Approach
(2022-06-03)Schizotypy refers to a set of personality traits that bear resemblance, at subclinical level, to psychosis. Despite evidence of similarity at multiple levels of analysis, direct comparisons of schizotypy and clinical ... -
Exploration of the microbiome-derived factors impacting human Langerhans cell function
(2023-04-28)Atopic dermatitis (AD) is the most common chronic inflammatory skin disease worldwide. AD skin is heavily colonized with S. aureus (S.a.) and exhibits low amounts of S. epidermidis (S.e.). In this thesis, different bacteria ... -
Exploring the Applicability of General Dietary Recommendations for People Affected by Obesity
(2023-03-25)(1) Obesity has emerged as a major public health challenge with increasing prevalence globally. The General Dietary Behavior Inventory (GDBI) was developed based on official dietary recommendations. However, little is known ... -
Additive prognostic impact of the cerebrospinal fluid arginine/ornithine ratio to established clinical scores in aneurysmal subarachnoid hemorrhage
(2023-04-14)Cerebrospinal fluid (CSF) metabolites are increasingly recognized as prognostic factors in aneurysmal subarachnoid hemorrhage (SAH). The CSF arginine/ ornithine ratio (Arg/Orn) was shown to predict cerebral vasospasms ... -
Reliability of Retinal Layer Annotation with a Novel, High-Resolution Optical Coherence Tomography Device: A Comparative Study
(2023-03-31)Optical coherence tomography (OCT) enables in vivo diagnostics of individual retinal layers in the living human eye. However, improved imaging resolution could aid diagnosis and monitoring of retinal diseases and identify ... -
Small Changes in Patient Arrival and Consultation Times Have Large Effects on Patients' Waiting Times: Simulation Analyses for Primary Care
(2023-01-18)(1) Background: Workflows are a daily challenge in general practices. The desired smooth work processes and patient flows are not easy to achieve. This study uses an operational research approach to illustrate the general ... -
P300 Modulation via Transcranial Alternating Current Stimulation in Adult Attention-Deficit/Hyperactivity Disorder: A Crossover Study
(2022-07-18)Objective: A repeated finding regarding event-related potentials (ERPs) is that patients with ADHD show a reduced P300 amplitude. This raises the question of whether the attention of ADHD patients can be increased by ... -
Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development
(2022-12-21)How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and ... -
Erhöhte Inanspruchnahme von Hausärzt*innen durch Patient*innen mit Gewalterfahrungen: Ergebnisse aus der repräsentativen Studie zur Gesundheit Erwachsener in Deutschland und der General Practice Care-1 Studie
(2023-04-20)<em>Hintergrund:</em> Gewalt ist ein wachsendes Problem im öffentlichen Gesundheitswesen und beeinflusst sowohl physische als auch mentale Gesundheit. Gewaltopfer suchen vermehrt Hilfe in medizinischen Einrichtungen, statt ... -
Extracellular Vesicles in Hepatobiliary Cancer Management
(2023-04-19)Cancer is a global health problem that will intensify in the upcoming years and decades. Hepatobiliary cancers, comprising hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and gallbladder carcinoma (GbCA), are among ... -
Einfluss von Mikro- und Makropapillen in der Glaukombildgebung
(2023-04-06)<strong>Hintergrund:</strong> Zur Papillenbeurteilung bei Glaukompatienten stehen verschiedene bildgebende Verfahren zur Verfügung. Anatomisch auffällige, große oder kleine Papillen können den Untersucher aber vor ...
