The Faculty of Mathematics and Natural Sciences: Search
Now showing items 1-10 of 17
Etablierung und Anwendung unterschiedlicher kolorimetrischer Detektionsmethoden zur Aktivitätsbestimmung von Modulatoren der ABC-Transporter ABCB1, ABCC1 und ABCG2
(2020-10-29)
Die Überexpression von ABC-Transportproteinen in Krebszellen führt zu Resistenzen gegenüber einem großen Spektrum antineoplastischer Substanzen. ABCB1, ABCC1 und ABCG2 sind die wichtigsten Vertreter, welche zu dieser ...
Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)
Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ...
In Silico Facets of Biochemical Research: Accounts from Protein Folding and Protein-Ligand Interaction Studies
(2020-09-04)
Exponential advancements in computer technology over the last five decades have ubiquitously benefited science and humanity as a whole. Consequent beneficiaries of this surge of computational power include all subfields ......
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
(2021-12-16)
In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ...
Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
(2020-02-07)
The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a ......
Die biologische Funktion der N1-2´O-Methylierung eukaryotischer mRNA durch die Methyltransferase CMTr1
(2021-05-14)
Eukaryoten modifizieren das 5´-Ende ihrer mRNA mit einem invertierten N7-methyliertem Guanosin (m7G). Diese Cap0 genannte Struktur wird in höheren Eukaryoten durch die Methyltransferase CMTr1 weiter modifiziert: CMTr1 ...
Chemoinformatics-Driven Approaches for Kinase Drug Discovery
(2020-01-07)
Given their importance for the majority of cell physiology processes, protein kinases are among the most extensively studied protein targets in drug discovery. Inappropriate regulation of their basal levels results in ...
Evolution of the Activity Cliff Concept and Practical Implications for Compound Design
(2021-07-22)
Entering the “big data” era, a number of different research areas have witnessed an enormous increase in data at an exponential rate. For drug discovery, various publicly available protein structure and compound bioactivity ...
γ-Hydroxybuttersäure (GHB)-Analytik zum Zweck der Verlängerung des Nachweisfensters einer exogenen GHB-Gabe sowie der Verbesserung der postmortalen Befundinterpretation
(2022-06-17)
Der endogene Neurotransmitter γ-Hydroxybuttersäure (GHB) stellt Gutachter in forensisch-toxikologischen Kontexten regelmäßig vor große Herausforderungen. Im Zusammenhang mit ungeklärten Todesfällen, Suiziden oder ...
Synthesis and structure-activity relationships of CD39 and CD73 inhibitors
(2022-08-13)
Ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1 or CD39) is a member of the membrane-bound ecto-nucleotidase family, which catalyzes the extracellular hydrolysis of pro-inflammatory ATP and pro-thrombotic ADP ......