Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Acceleration of microglial clearance function by small TREM2-activating anionic disaccharides
(2014-07-29)
Triggering receptor expressed on myeloid cells-2 (TREM2) is an innate immune receptor, which is expressed on myeloid cells, like microglia inside the central nervous system. TREM2 signals via the adaptor protein DAP12. ...
Fluorine-18 labeling and simultaneous glycosylation of the model peptide demobesin 1 by the novel prosthetic group, keto-[18F]FDG
(2014-07-23)
With the development of keto-[18F]FDG in this work a new powerful prosthetic group for labeling of carbonyl reactive compounds has been added to the tools available for labeling biomelecules with the radionuclide ...
Reverse engineering of biological signaling networks via integration of data and knowledge using probabilistic graphical models
(2014-10-29)
Motivation
The postulate that biological molecules rather act together in intricate networks, pioneered systems biology and popularized the study on approaches to reconstruct and understand these networks. These ...
The postulate that biological molecules rather act together in intricate networks, pioneered systems biology and popularized the study on approaches to reconstruct and understand these networks. These ...
Wohnstandortentscheidungen von Doppelverdienerhaushalten: Zum Zusammenwirken von Wohnen und Arbeiten in der polyzentrischen Stadtregion Köln / Bonn
(2014-11-26)
Veränderungen in Gesellschaft und Arbeitswelt haben dazu geführt, dass die Zahl der Doppelverdienerhaushalte stark gestiegen ist und sie einen großen Anteil in der Gesellschaft einnehmen. Gleichzeitig ist zu beobachten, ...
Weak lensing measurements for the APEX-SZ cluster survey
(2014-12-02)
The formation of structures in the universe, such as galaxy clusters, depends sensitively on cosmological parameters. Measuring the abundance of clusters as a function of mass and redshift therefore yields a way to constrain ...
The Impact of Sensor Characteristics and Data Availability on Remote Sensing Based Change Detection
(2014-12-04)
Land cover and land use change are among the major drivers of global change. In a time of mounting challenges for sustainable living on our planet any research benefits from interdisciplinary collaborations to gain an ...
Massive Black Holes in Galaxies
(2014-10-16)
After summarizing the current status of black hole related research, I investigate the angular momentum driven flux of stars onto supermassive black hole (SMBH) loss cone orbits by means of direct NBODY6 computations. By ...
Wachstumsverhalten fokaler hepatozellulärer Veränderungen in Putenembryonen und die Wirkung von Sorafenib und Cisplatin auf normale und präneoplastische Zellen
(2014-11-28)
In der vorliegenden Arbeit wurde die Möglichkeit der embryonalen Putenleber als Modell zum Test potenzieller Tumortherapeutika untersucht. Es konnten verlässlich fokale hepatozelluläre Veränderungen (foci of altered ...
Funktionsmorphologische Untersuchungen abdominaler Infrarot-Rezeptoren von Insekten
(2014-12-12)
Infrarot (IR) -Rezeptoren sind innerhalb der Insekten offensichtlich mehrfach unabhängig voneinander entstanden. Bei den Vertretern der Gattung Melanophila, einigen Rindenwanzen der Gattung Aradus und bei dem australischen ...
Identification of novel cytosolic binding partners of the neural cell adhesion molecule NCAM and functional analysis of these interactions
(2014-12-04)
The neural cell adhesion molecule (NCAM) plays an important role during brain development and in adult brain. NCAM functions through interactions with several proteins leading to intracellular signal transduction pathways ...