Mathematisch-Naturwissenschaftliche Fakultät: Suche
Anzeige der Dokumente 161-170 von 220
A humanized zebrafish screening platform to identify GPR17 inhibitors for the treatment of multiple sclerosis
(2020-02-19)
Multiple sclerosis (MS), a demyelinating disease of the central nervous system (CNS) with dev-astating symptoms, is characterized by the progressive destruction of myelin and myelinating oligodendrocytes (Ol). Currently, ...
Functional analysis of molars in “symmetrodontan” mammals
(2020-03-10)
The “symmetrodontan” molar pattern is characterized by triangulation of the main cusps in combination with a reversed-triangle occlusion. In the fossil record, the “symmetrodontan” molar pattern occurred in various taxa ......
Pharmacological reprogramming of macrophages through aptamiRs
(2020-03-05)
Nucleic acid-based molecules have certain advantages over conventional drugs or protein-based target approaches. Chemically synthetized nucleic acids-based molecules are known as aptamers. They are selected from a combinatorial ...
Molecular and biochemical studies of the Craterostigma plantagineum cell wall during dehydration and rehydration
(2020-02-17)
Craterostigma plantagineum belongs to the desiccation tolerant angiosperm plants. Upon dehydration leaves fold and the cells shrink which is reversed during rehydration. To understand this process changes in cell wall ......
Recognition of cytosolic 3´P DNA & The role of GCET2+ DCs in cross-presentation
(2020-04-01)
In mammalian cells, DNA is confined to the nucleus and mitochondria. Detection of DNA in other compartments like the cytoplasm indicates danger and infection. Our research group has previously discovered that 3´monophosphate ...
Study of Excited Ξ Baryons in Anti-Proton Proton Collisions with the PANDA Detector
(2020-02-11)
Understanding the excitation pattern of baryons is indispensable for the understanding of non-perturbative QCD. Up to now only the nucleon excitation spectrum has been subject to systematic experimental studies, in contrast ...
Biochemical and structural characterization of the NLRP3 inflammasome
(2020-02-13)
The innate immune system utilizes inflammasome proteins to recognize danger signals and to fight invading pathogens. To date, the most studied inflammasome protein is NLRP3 - a multidomain protein, composed of a N-terminal ...
Characterization of Ceramide synthase 2 dysfunctions caused by targeted mutations in transgenic mice
(2020-02-10)
Ceramide species are the precursor of sphingolipids, which serve as structural components of biological membranes or are bioactive molecules. In mammals, ceramides are synthesised by a family of ceramide synthases (CerS) ......
3-D Cloud Morphology and Evolution Derived from Hemispheric Stereo Cameras
(2020-02-11)
Clouds play a key role in the Earth-atmosphere system as they reflect incoming solar radiation back to space, while absorbing and emitting longwave radiation. A significant challenge for observation and modeling pose cumulus ...