The Faculty of Mathematics and Natural Sciences: Search
Now showing items 21-30 of 37
Impact of UGT1A polymorphisms on inflammation and fibrogenesis in a humanized transgenic mouse model
(2020-07-07)
Fibrogenesis represents a highly dynamic scarring response of the liver resulting from different causes of hepatic injury. A key process capable of activating a broad array of profibrogenic pathways is oxidative stress. ...
Verbesserung der Befundinterpretation bei forensisch-toxikologischen Fragestellungen am Beispiel von Prothipendyl, Cannabinoiden und neuen psychoaktiven Substanzen: Bedeutung von Metaboliten und Referenzdaten
(2020-01-06)
Für eine umfassende forensisch-toxikologische Interpretation von Substanznachweisen in biologischen Matrizes bedarf es einer fundierten Datenlage. Neben pharmakologischen bzw. toxikologischen Eigenschaften der Substanzen ...
Climate field reconstructions from pollen and macrofossil syntheses using Bayesian hierarchical models
(2020-01-09)
Studying past climate states is important to understand climate changes and climate variability on centennial to orbital timescales, to analyze the reaction of the Earth system to large-scale changes in external forcings, ...
Biodiversity of Marine Heterobranchia (Gastropoda) around North Sulawesi Indonesia
(2020-07-24)
North Sulawesi province is one of the most potential areas in terms of natural marine resources. In North Sulawesi there are many interesting tourist places with high marine biodiversity and many objects are currently under ...
Mining and small-scale farming in the Andes: Socio-environmental roots of land-use conflict
(2020-04-08)
The Peruvian Andes are one of the most important water sources for the country. Therefore, their exploitation might pose critical threats for local farming activities, national economy, and water quantity and quality. At ...
Design, Entwicklung und Herstellung modifizierter gastroretentiver schwimmender Systeme auf Basis von schmelzextrudierten hohlen Zylindermatrices
(2020-04-15)
Die Entwicklung gastroretentiver Arzneiformen ist komplex, da neben der kontrollierten Freisetzung des Wirkstoffs zusätzlich die Verlängerung der Verweilzeit im Magen gewährleistet werden muss. Hierfür werden meist hydrophile ...
Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients
(2020-03-19)
The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order ...
A humanized zebrafish screening platform to identify GPR17 inhibitors for the treatment of multiple sclerosis
(2020-02-19)
Multiple sclerosis (MS), a demyelinating disease of the central nervous system (CNS) with dev-astating symptoms, is characterized by the progressive destruction of myelin and myelinating oligodendrocytes (Ol). Currently, ...
Ryanodine Receptor 2 (RyR2) underlies maintenance and remodeling of dendritic spines
(2020-03-09)
The human brain comprises 1012 neurons that receive, integrate and transmit electrochemical signals. This complex network constantly re-adapts during an animal’s lifetime. All sensed experiences refine neurons via ...