Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Bewertung von pharmakokinetischen Parametern zur Phänotypisierung des menschlichen Cytochrom P450 Enzyms CYP2D6 mittels Dextromethorphan
(2009-04-14)
Der Umsatz von Dextromethorphan (DEX) zu dessen CYP2D6 abhängig gebildeten Metaboliten Dextrorphan (DOR) wird seit langer Zeit für die CYP2D6 Phänotypisierung verwendet, jedoch fehlt es bislang an einer systematischen ...
Heterogenität humaner 5-HT3-Rezeptoren: Pharmakologische Charakterisierung homopentamerer 5-HT3A-, heteromerer 5-HT3A/B(C,D,E)-Rezeptoren und natürlich vorkommender 5-HT3-Rezeptorvarianten
(2009-04-07)
Der 5-HT3-Rezeptor ist innerhalb der Familie der Serotonin (5-HT)-Rezeptoren der einzige ligandgesteuerte Ionenkanal. Er zählt zur Superfamilie der Cys-loop-Rezeptoren und setzt sich aus fünf konzentrisch um eine ...
Biosynthesis of soluble capsule precursors in Staphylococcus aureus
(2016-11-28)
Most invasive pathogens produce polysaccharide capsules, which play an essential role in conferring protection against host immune defense. In the case of Staphylococcus aureus, most clinical isolates are encapsulated, and ......
Chelation as a strategy with the potential to overcome multidrug resistance in cancer
(2016-09-02)
According to the World Health Organisation cancer is the second leading cause of death in industrialized countries. In many cases treatment fails due to the development of resistance against multiple (structurally and ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...
Oxytocin – the prosocial molecule?: Intranasal oxytocin effects on social approach behavior, social cognition, volitional and emotional ambivalence in healthy human beings
(2015-10-30)
Oxytocin (OXT) is a highly conserved neuropeptide, regarding both its chemical structure and its functionality. It has been traced back at least 700 million years. OXT’s fundamental role lies in reproduction and parenting ...
Proteomische Funktionsanalyse humanbiologischer Systeme mittels chemisch modifizierter Proteine
(2016-04-18)
Das humane Proteom unterliegt gegenüber dem eher statischen Genom einem kontinuierlichen Auf- und Abbau. Diese Dynamik zeigt sich durch ein mehrschichtiges Muster an Protein-Protein Interaktionen.
Im ersten Teil ...
Im ersten Teil ...
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
(2021-12-16)
In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ...
Identification, optimization and characterization of pharmacological tools for the cannabinoidactivated orphan G protein-coupled receptor GPR18 and related receptors
(2017-12-21)
Cannabinoid receptors comprise two classical subtypes, CB1 and CB2, which belong to the large family of G protein-coupled receptors (GPCRs). They are the major targets of cannabinoids such as ......
Purines and 9-deazapurines as Modulators of Multidrug Resistance-associated Protein 1 (MRP1/ABCC1)-mediated Transport
(2017-11-14)
Expression of ABC-transport proteins is a major obstacle in cancer chemotherapy. Especially MRP1, P-gp and BCRP are expressed in different malignancies like lung cancer, colon carcinomas, leukemias, bladder cancer, myeloma, ...