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Functional Modulation of Activated Protein C using DNA-Aptamers
(2017-03-15)
Aptamers are single stranded DNA or RNA oligonucleotides which are able to interact with their designated target molecules with high affinity and specificity. The in-vitro procedure used for aptamer selection from a randomly ...
Systematics, Taxonomy, and Evolution of Urtica L. (Urticaceae)
(2017-04-25)
The systematics of Urtica have puzzled scientists for the past 200 years and no single comprehensive attempt at understanding infrageneric relationships has been published in the past, nor have species delimitations ...
Neuronal Systems Potentially Involved in Autism Spectrum Disorder
(2017-06-01)
Pfn2 is a brain specific actin binding protein involved in actin dynamics. The Pfn2 knock-out mouse model shows an autistic-like phenotype with all of the features commonly reported in autism patients such as social and ......
Development of efficient tools for monitoring and improvement of biogas production
(2017-03-29)
Biomass from energy crops and organic waste is one of the most important renewable energy sources and can be used for the production of biogas. Biogas formation is based on the fermentation of organic matter and is performed ...
Immune regulation in Plasmodium berghei ANKA infected mice either lacking type I interferon signalling or mimicking malaria tolerance
(2017-03-16)
Malaria is a disease caused by Plasmodium parasites and transmitted by female Anopheles mosquitoes. Children under the age of five, pregnant women and none-immune individuals are at risk of developing severe malaria such ......
Malaria ist eine Krankheit, die durch eine Infektion mit Parasiten der Gattung Plasmodium entsteht und durch weibliche Anopheles Mücken übertragen wird. Besonders Kinder unter 5 Jahren, schwangere Frauen und nicht-immune ......
Malaria ist eine Krankheit, die durch eine Infektion mit Parasiten der Gattung Plasmodium entsteht und durch weibliche Anopheles Mücken übertragen wird. Besonders Kinder unter 5 Jahren, schwangere Frauen und nicht-immune ......
Diversity and Evolutionary Origin of the Virus Family Bunyaviridae
(2017-01-17)
The family Bunyaviridae is one of the largest groups of viruses and contains more than 350 taxa. Five genera are assigned to the family, namely Hantavirus, Nairovirus, Orthobunyavirus, Phlebovirus, and Tospovirus. Most ......
Patientenspezifische induziert pluripotente Stammzellen als Modellsystem zur Untersuchung der lysosomalen Speichererkrankung Metachromatische Leukodystrophie
(2017-01-04)
Die Metachromatische Leukodystrophie (MLD) wird verursacht durch eine funktionelle Defizienz des metabolischen Enzyms Arylsulfatase A (ARSA). Unter physiologischen Bedingungen baut ARSA das Membranlipid 3’-O-Sulfo-Galakt ......
Generierung und Charakterisierung eines in vivo Modells zur BAG3P209L-Mutation im Herzmuskel
(2017-01-04)
Myofibrilläre Myopathien sind Erkrankungen der Muskulatur mit teilweiser Beteiligung der Herzmuskulatur, die oft einen frühzeitigen Tod zur Folge haben. Dabei macht sich das Leitsymptom einer Myofibrillären Myopathie, eine ......
Biological functions of Sphingomyelin synthase related protein and Ceramide synthase 4 investigated with transgenic mouse mutants
(2017-01-04)
Previously, it was reported that the catalytic activity of the sphingomyelin synthase related protein (SMSr) is essential to prevent ceramide accumulation and disruption of the early secretory pathway in cultured HeLa ...
Membrane-model systems to study EGFR-ARNO interaction
(2017-01-04)
Transmembrane proteins are involved in important biological functions, such as in transport of molecules, and in signal transduction. They represent almost 25 % of the proteome and constitute important drug targets. The ...