The Faculty of Mathematics and Natural Sciences: Search
Now showing items 11-20 of 22
Molecular mechanisms involved in midbrain dopaminergic neuron migration during murine development
(2014-04-16)
Midbrain dopaminergic (MbDA) neurons are located in the ventral tegmental area (VTA) and the substantia nigra (SN) and are involved in many brain functions including motor control, reward associated behavior and modulation ...
Plexin-A2 and neuropilin-2 in the axonal guidance of cranial nerves in avian embryos
(2014-03-17)
Secreted class-III semaphorins exert their effects in axon guidance and neuronal migration by binding with receptors, such as plexins and neuropilins. Neuropilins are insufficient to convey signals of their own; rather, ......
Die Rolle von Plexin-A2 und Neuropilin-2 bei der axonalen Wegfindung von Hirnnerven im Vogelembryo
Sezernierte Klasse-III Semaphorine entfalten ihre Wirkung auf die Wegfindung der Axone und die ......
Die Rolle von Plexin-A2 und Neuropilin-2 bei der axonalen Wegfindung von Hirnnerven im Vogelembryo
Sezernierte Klasse-III Semaphorine entfalten ihre Wirkung auf die Wegfindung der Axone und die ......
Pseudomycoicidin, a novel lantibiotic produced by Bacillus pseudomycoides
(2014-09-12)
The continuous increase of antibiotic resistant pathogens necessitates a search for new antibiotics. In this study a novel lantibiotic gene cluster was identified using the publicly available genome database. Blast searches ......
Protein-protein interactions in human pluripotent stem cell-derived neural stem cells and their neuronal progeny
(2014-09-29)
While most approaches in cell-based disease modeling are focused on the effects of defined mutations on the molecular or cellular phenotype, the assessment of underlying alterations in the interactomes of disease-relevant ...
Untersuchungen zur antiviralen Aktivität des humanen Zinkfinger antiviralen Proteins gegen Alphaviren
(2014-09-11)
Das Zinkfinger antivirale Protein (ZAP) wurde als antiviraler Wirtsfaktor identifiziert, der die Replikation und Verbreitung verschiedener Viren inhibiert. In der vorliegenden Arbeit wurde die antivirale Aktivität der ...
Intrazerebroventrikuläre Enzymersatztherapie der metachromatischen Leukodystrophie
(2014-09-25)
Die metachromatische Leukodystrophie (MLD) ist eine autosomal rezessiv vererbte lysosomale Speicherkrankheit. Diese wird durch einen Gendefekt der Arylsulfatase A (ASA) verursacht, welche den ersten Schritt in der Degradation ......
Role of antimicrobial peptides in metabolism and innate immunity in Drosophila melanogaster
(2014-08-12)
“Metabolism” and “Immunity” are two essential, recognized and independent functions of animal kingdom. They have their own biological cycle independent of each other. While metabolism contributes, amongst other things, to ...
Acceleration of microglial clearance function by small TREM2-activating anionic disaccharides
(2014-07-29)
Triggering receptor expressed on myeloid cells-2 (TREM2) is an innate immune receptor, which is expressed on myeloid cells, like microglia inside the central nervous system. TREM2 signals via the adaptor protein DAP12. ...
Wachstumsverhalten fokaler hepatozellulärer Veränderungen in Putenembryonen und die Wirkung von Sorafenib und Cisplatin auf normale und präneoplastische Zellen
(2014-11-28)
In der vorliegenden Arbeit wurde die Möglichkeit der embryonalen Putenleber als Modell zum Test potenzieller Tumortherapeutika untersucht. Es konnten verlässlich fokale hepatozelluläre Veränderungen (foci of altered ...
Functional characterization of neuron-NG2 cell synaptic transmission
(2014-09-11)
NG2 cells are nowadays considered as a fourth class of glial cells in the CNS. They express various types of voltage-gated ion channels and neurotransmitter receptors and exhibit the capability to proliferate and differentiate. ...