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Molecular mechanisms involved in midbrain dopaminergic neuron migration during murine development
(2014-04-16)
Midbrain dopaminergic (MbDA) neurons are located in the ventral tegmental area (VTA) and the substantia nigra (SN) and are involved in many brain functions including motor control, reward associated behavior and modulation ...
Plexin-A2 and neuropilin-2 in the axonal guidance of cranial nerves in avian embryos
(2014-03-17)
Secreted class-III semaphorins exert their effects in axon guidance and neuronal migration by binding with receptors, such as plexins and neuropilins. Neuropilins are insufficient to convey signals of their own; rather, ......
Die Rolle von Plexin-A2 und Neuropilin-2 bei der axonalen Wegfindung von Hirnnerven im Vogelembryo
Sezernierte Klasse-III Semaphorine entfalten ihre Wirkung auf die Wegfindung der Axone und die ......
Die Rolle von Plexin-A2 und Neuropilin-2 bei der axonalen Wegfindung von Hirnnerven im Vogelembryo
Sezernierte Klasse-III Semaphorine entfalten ihre Wirkung auf die Wegfindung der Axone und die ......
Pseudomycoicidin, a novel lantibiotic produced by Bacillus pseudomycoides
(2014-09-12)
The continuous increase of antibiotic resistant pathogens necessitates a search for new antibiotics. In this study a novel lantibiotic gene cluster was identified using the publicly available genome database. Blast searches ......
Protein-protein interactions in human pluripotent stem cell-derived neural stem cells and their neuronal progeny
(2014-09-29)
While most approaches in cell-based disease modeling are focused on the effects of defined mutations on the molecular or cellular phenotype, the assessment of underlying alterations in the interactomes of disease-relevant ...
Untersuchungen zur antiviralen Aktivität des humanen Zinkfinger antiviralen Proteins gegen Alphaviren
(2014-09-11)
Das Zinkfinger antivirale Protein (ZAP) wurde als antiviraler Wirtsfaktor identifiziert, der die Replikation und Verbreitung verschiedener Viren inhibiert. In der vorliegenden Arbeit wurde die antivirale Aktivität der ...
Intrazerebroventrikuläre Enzymersatztherapie der metachromatischen Leukodystrophie
(2014-09-25)
Die metachromatische Leukodystrophie (MLD) ist eine autosomal rezessiv vererbte lysosomale Speicherkrankheit. Diese wird durch einen Gendefekt der Arylsulfatase A (ASA) verursacht, welche den ersten Schritt in der Degradation ......
Consequence of FA2H Deficiency and FA2H Interaction Partners Revealed by Proteomic Analyses
(2015-03-10)
Fatty acid-2 hydroxylase (FA2H) is a 43 kDa transmembrane protein residing in the endoplasmic reticulum. As a monooxygenase it is responsible for the alpha–hydroxylation of fatty acids, which are later incorporated into ...
RNA aptamers as selective protein kinase inhibitors: New molecular tools for the elucidation of signal transduction pathways
(2015-04-16)
Elucidating the precise function of individual protein kinases within complex signal transduction cascades represents one of the greatest challenges in molecular biology. Protein kinases are enzymes that catalyze the ...
Genetics of schizophrenia: Contribution of rare and low-frequency sequence variants in selected genomic regions to disease susceptibility
(2015-03-27)
Schizophrenia is a highly heritable, multifactorial mental disorder. Up to date, a number of common SNPs with low penetrance and large rare structural variants (CNVs) with higher penetrance have been identified to contribute ......
Tetraspanin web formation and function
(2015-03-13)
The cell membrane is crucial for living cells; it encloses the intracellular matrix, maintains the concentration of cytosolic components, and controls the in-/outward signalling and interaction pathways. The cell membrane ...