The Faculty of Mathematics and Natural Sciences: Search
Now showing items 31-40 of 58
In silico, in vitro und in vivo Charakterisierung der Hemmung ausgewählter Fremdstoff-metabolisierender Enzyme des Menschen durch Voriconazol
(2016-04-12)
Zur Präzisierung des inhibitorischen Potentials des etablierten Antimykotikums Voriconazol auf ausgewählte, den Midazolam-Metabolismus betreffende Enzyme wurden Inhibitionsstudien in vitro und in vivo durchgeführt, um ...
The role of the Hippo pathway in etiology and progression of pancreato-biliary tumors and clear cell renal cell carcinoma
(2016-01-21)
In the quest for the discovery of novel targets for cancer therapy, aberrantly reactivated embryonic signaling pathways have proven to be a rich mine and recent years have seen the introduction of the hedgehog-inhibitor ...
Natural product chemistry and biosynthetic studies of secondary metabolites from the marine-derived fungus Stachylidium sp.
(2016-03-22)
The fungal kingdom has made considerable contributions to the production of peptide secondary metabolites, many of them with therapeutic potential, e.g. the immunosuppressant cyclosporine and the antifungal echinocandins. ...
Arzneimitteltherapiesicherheit älterer, pflegebedürftiger Patienten in der stationären Versorgung unter besonderer Berücksichtigung der Schnittstellen im Behandlungsprozess
(2016-01-20)
Ziel der vorliegenden Arbeit war es, zu untersuchen, ob Patienten an einem Universitätsklinikum von einer stationären Pharmazeutischen Betreuung profitieren. In einer Vorphase wurde zunächst auf verschiedenen Normalstationen ...
Identification, optimization and characterization of pharmacological tools for the cannabinoidactivated orphan G protein-coupled receptor GPR18 and related receptors
(2017-12-21)
Cannabinoid receptors comprise two classical subtypes, CB1 and CB2, which belong to the large family of G protein-coupled receptors (GPCRs). They are the major targets of cannabinoids such as ......
Synaptic vesicle protein 2A (SV2A) and connexin 43 (Cx43) as targets for epilepsy: establishment of assays and identification of ligands
(2017-09-12)
Epilepsy is a chronic neurological disorder affecting around 1% of the human population worldwide. The antiepileptic drugs (AEDs) available on the market provide symptomatic relief from epilepsy but do not cure the disease. ...
Cardiac L-type calcium channels and expression of RGK proteins in mouse models associated with type 2 diabetes
(2017-10-19)
Introduction: Cardiovascular disease, such as diabetic cardiomyopathy (DCM) and resulting heart failure (HF), is a leading cause of death for diabetic patients.
In ventricles of non-diabetic HF ...
In ventricles of non-diabetic HF ...
Alk7 signaling and direct lentivirus injection as novel approaches to investigate brown fat development and function
(2017-05-15)
The obesity pandemic is increasing worldwide and is a major threat to human health. Comorbidities associated with obesity are type 2 diabetes, cardiovascular disorders, non-alcoholic fatty liver disease and even some types ...
Enzyme-inhibitory secondary metabolites and their exudation in the marine-derived fungus Epicoccum nigrum link
(2017-04-25)
The kingdom of fungi harbors a huge diversity of life forms. The Ascomycota in particular are a prolific source of medicinal drugs and new lead structures with potent bioactivities. During this work, two marine-derived ......
Feasibility and Efficacy of a Collaborative Medication Management for Elderly, Multimorbid Patients
(2017-08-29)
Medication Review and Medication Management are new pharmaceutical care services with a strong potential to contribute to patients’ health care outcomes. The aim of this work was to evaluate an interprofessional, collaborative ...