Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Hydrophilic Ionic Liquid Mixtures of Weakly and Strongly Coordinating Anions with and without Water
(2018-08)
With the aid of ab initio molecular dynamics simulations, we investigate an ionic liquid (IL) mixture composed of three components 1-butyl-3-methylimidazolium [C4C1Im]+, ...
Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)
(2018-03-12)
The treatment of cancer with chemotherapeutic drugs is strongly limited by intrinsic or aquired resistance of the cancer cells. This is the main reason of a failure of the therapy. The cellular resistance mostly originates ...
Development and Application of Efficient Methods for the Computation of Electronic Spectra of Large Systems
(2018-04-13)
In this thesis, an efficient procedure to compute electronic excitation spectra of molecular systems is presented, focusing particularly on the computation of electronic circular dichroism (ECD) spectra. ECD spectroscopy ...
Identifizierung und Charakterisierung neuartiger Oxidoreduktasen in Gluconobacter oxydans und Produktion des potentiellen Süßstoffes 5-Keto-D-Fruktose
(2018-04-10)
Thema der vorliegenden Arbeit war die Identifizierung und Charakterisierung unbekannter PQQ- und FAD-abhängiger Oxidoreduktasen, deren regiospezifische Umsetzung von Substraten in Hinblick auf die Entwicklung biotechnologischer ......
Biologicals and Biosimilars: Differences and implementation of the regulatory requirements in the European Union versus those in the United States with special consideration and analysis of the implementation and improvement of safety standards for biosimilar products
(2018-06-08)
What safety relevant standards are established for biotechnology-derived biosimilar products in both the European Union (EU) and the USA? And, is there potential to improve the current safety standards? The applicable ...
Syntheses and structure-activity relationships of novel P2X3 receptor antagonists
(2018-04-19)
P2X3 receptors are ligand-gated ion channels activated by extracellular adenosine-5’-triphosphate (ATP). Activation of the P2X3 receptors has been linked to several pathophysiological conditions including inflammation and ...
Molekulare Mechanismen idiosynkratischer Medikamenten-vermittelter Leberschädigung
(2018-04-13)
Idiosynkratischer Medikamenten-induzierter Leberschaden (engl.: idiosyncratic drug induced liver injury, iDILI) stellt ein gravierendes Problem in der Medikamentenentwicklung und der klinischen Erforschung von Medikamenten ...
Metabolites of bacteria isolated from marine environments: chemistry and bioactivities
(2018-04-19)
Roseovarius oyster disease (ROD) is a bacterial-induced infection and causes major problems in oyster aquaculture. Bacteria of the genus Labrenzia have been proposed as protective agents against ROD. The here investigated ...
Airborne Navigation by Fusing Inertial and Camera Data
(2018-04-13)
Unmanned aircraft systems (UASs) are often used as measuring system. Therefore, precise knowledge of their position and orientation are required.
This thesis provides research in the conception and realization of a ...
This thesis provides research in the conception and realization of a ...
Functional Characterization of Interaction Partners of the Co-Chaperone BAG3
(2018-04-23)
Protein homeostasis (proteostasis) describes the cellular balance between protein synthesis, function and degradation. The stress inducible co-chaperone BAG3 is a key factor in proteostasis, in particular under mechanical ...