The Faculty of Mathematics and Natural Sciences: Search
Now showing items 1-9 of 9
Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)
Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ...
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
(2020-11-16)
Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Totalsynthesen neuartiger Leupylogs: vereinfachte Strukturanaloga der Leupyrrine
(2020-06-03)
Die vorliegende Dissertation behandelt die totalsynthetische Darstellung von neuartigen Strukturanaloga der Leupyrrine. Diese Stoffklasse myxobakterieller Sekundärmetabolite zeichnet sich durch die Kombination einzigartiger ......
Total Synthesis of novel Leupylogs – simplified Structural Analogues of Leupyrrins
This submitted thesis deals with the development of the total synthesis of novel Leupylogs, structural leupyrrin ......
Total Synthesis of novel Leupylogs – simplified Structural Analogues of Leupyrrins
This submitted thesis deals with the development of the total synthesis of novel Leupylogs, structural leupyrrin ......
Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
(2020-02-07)
The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a ......
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A receptors
(2021-09-22)
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A ...
Modulation der Gαi1/s-Proteinaktivität durch lineare und makrozyklische Peptide
(2021-07-08)
Die vorliegende Dissertation beschäftigt sich mit der Identifizierung und Charakterisierung von peptidischen Modulatoren für die Gαi/s-Proteinaktivität. Die Ga-Untereinheit heterotrimerer G-Proteine ist eine bedeutende ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
In situ observations of reaction and transport phenomena during silicate glass corrosion by fluid-cell Raman spectroscopy: Method development and applications
(2020-07-06)
Borosilicate glass is the preferred material for the immobilization of high-level nuclear waste and an important material for various industries. Silicate glasses, however, are prone to corrosion by aqueous solutions, which ......
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...