Mathematisch-Naturwissenschaftliche Fakultät: Suche
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The Role of TRIM71 in Male Germ Cell Development
(2020-09-02)
Germ cells are the key to continuation of life as they are the unique cell lineage capable to transfer the complete genetic information to the next generation. Both, infertility and testicular cancers are usually originating ......
The role of YAP signaling in thermogenic adiposetissues
(2021-01-02)
One of major metabolic organs, brown adipose tissue (BAT), is responsible for energy expenditure through uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis, which has been considered a promising pharmacological ...
Electrophysiological and pharmacological in vivo characterization of EEG fingerprints / biomarkers in AD mouse models
(2021-01-19)
Alzheimer’s disease (AD) is a major leading cause of deaths worldwide with underlying conditions of dementia and cognitive decline mostly in older age patients (≥ 65 years). Currently, there are approximately 50 million ...
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
(2021-01-19)
Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ...
The role of GPR111 in adipose tissue
(2021-05-21)
Due to obesity pandemic and limited therapeutic approaches, novel targets of pharmaceutical treatments are urgently needed. AT as a very important metabolic organ is an attractive target for combating obesity and obesity ......
Identification of Intracellular Protein Binding Partners of Cisplatin and Their Role in Acquired and Intrinsic Resistance
(2021-03-18)
Cisplatin is a widely used drug in treatment of various solid tumors, amongst others ovarian cancer. However, whereas acquired resistance significantly limits therapy success, some tumors such as colorectal cancer are ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
(2020-11-16)
Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies into measuring the Higgs CP-state in H → ττ decays at ATLAS
(2020-07-16)
Since the discovery of the Higgs boson in 2012, experimental particle physics made large efforts to measure all properties of the new particle to characterise all its properties as precisely as possible.
So far, all ...
So far, all ...
Totalsynthesen neuartiger Leupylogs: vereinfachte Strukturanaloga der Leupyrrine
(2020-06-03)
Die vorliegende Dissertation behandelt die totalsynthetische Darstellung von neuartigen Strukturanaloga der Leupyrrine. Diese Stoffklasse myxobakterieller Sekundärmetabolite zeichnet sich durch die Kombination einzigartiger ......
Total Synthesis of novel Leupylogs – simplified Structural Analogues of Leupyrrins
This submitted thesis deals with the development of the total synthesis of novel Leupylogs, structural leupyrrin ......
Total Synthesis of novel Leupylogs – simplified Structural Analogues of Leupyrrins
This submitted thesis deals with the development of the total synthesis of novel Leupylogs, structural leupyrrin ......