The Faculty of Mathematics and Natural Sciences: Search
Now showing items 1-10 of 21
In Silico Facets of Biochemical Research: Accounts from Protein Folding and Protein-Ligand Interaction Studies
(2020-09-04)
Exponential advancements in computer technology over the last five decades have ubiquitously benefited science and humanity as a whole. Consequent beneficiaries of this surge of computational power include all subfields ......
Effect of neural ablation of sphingosine-1-phosphate lyase (SGPL1) in glial cells
(2021-11-24)
Sphingosine-1-phosphate (S1P) is an evolutionarily conserved catabolic intermediate of sphingolipid metabolism that regulates diverse biological processes in the brain, including neural development, differentiation, and ...
Die konvergente Totalsynthese von Ajudazol A über Oxazolmodifikationen
(2020-07-14)
In der vorliegenden Dissertation wird die erste Totalsynthese von Ajudazol A, einem Vertreter der Naturstofffamilie der Ajudazole, beschrieben. Da diese zu den Polyketiden gehörende Naturstoffklasse selektiv die mitochondriale ...
Simultaneous identification of nucleotide-modified aptamers with different properties by multiplexed click-SELEX
(2020-06-18)
Voltage-gated sodium channels (VGSC) are important key regulators in excitable tissue that initiate and propagate the action potential in specifically excitable tissue such as brain nerves or muscle. In order to understand ...
Influence of the St. John's Wort Extract Ze117 on the Lipidome of PBMC and on the Lateral Diffusion of ß1-Adrenergic Receptors in C6 Cells
(2021-03-18)
Stress causes pathological changes in the signal transduction of neurotransmitter systems, which can lead to depression. Signaling relies not only on receptor-ligand interactions and subsequent regulatory processes, but ...
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
(2020-11-16)
Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Analyse der intranukleären Dynamik und des Exports der ribosomalen 60S-Untereinheit
(2021-09-13)
Die Proteinbiosynthese wird von Ribosomen - großen molekularen Maschinen - durchgeführt, die aus zahlreichen verschiedenen Proteinen und einem ribosomalen RNA-Rückgrat bestehen. Die Biogenese der ribosomalen Untereinheiten ...
Advanced migration assays for studying chemotaxis of slow moving cells
(2021-12-16)
Chemotaxis of slow moving cells plays a crucial role in numerous physiological and pathophysiological processes; including tumour metastasis, development, and wound healing. Therefore, a comprehensive understanding of ...
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
(2021-12-16)
In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ...
Die biologische Funktion der N1-2´O-Methylierung eukaryotischer mRNA durch die Methyltransferase CMTr1
(2021-05-14)
Eukaryoten modifizieren das 5´-Ende ihrer mRNA mit einem invertierten N7-methyliertem Guanosin (m7G). Diese Cap0 genannte Struktur wird in höheren Eukaryoten durch die Methyltransferase CMTr1 weiter modifiziert: CMTr1 ...