The Faculty of Mathematics and Natural Sciences: Mathematisch-Naturwissenschaftliche Fakultät: Recent submissions
Now showing items 361-380 of 5043
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Adaptive Geospatial Data Representation for Data Analytics and Sharing in the Mobility Domain
(2025-02-25)In recent years, the mobility domain has gained attention from urban planners and researchers due to its essential role in enhancing urban safety and development. This interest can be attributed to the increased availability ... -
Development of the first geldanamycin-based HSP90 degraders
(2023-06-28)Despite the early clinical promise, adverse events such as acquired resistance and dose-limiting toxicities have barred the widespread use of HSP90 inhibitors as anticancer drugs. A new approach involving proteolysis-targeting ... -
A Systematic Database Approach to Identify Companion Diagnostic Testing in Clinical Trials under the New In Vitro Diagnostic Medical Devices Regulation
(2023-06-12)The European Union In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746 (IVDR) introduces companion diagnostics (CDx) as a new legal term. CDx are applied in combination with a medicinal product to identify patient ... -
Quantum optimal transport for AF-C*-algebras
(2025-02-14)We introduce quantum optimal transport of states on tracial AF-C*-algebras to study non-spatial transport of quantum information, and view it as the pointwise case of a general parametrised one. We define quantum optimal ... -
A Cell Panel to Characterise Tau Aggregation
(2025-02-13)Tauopathies are neurodegenerative diseases characterised by the pathological folding of Tau into highly ordered, β-sheet rich fibrils (so-called amyloid), which progressively spread through the central nervous system in a ... -
Betrachtung des Zellmetabolismus mit Fokus auf Hexokinase 2 und IGFBP-2 im Tumorresistenzgeschehen
(2025-02-11)Bei der Behandlung solider Tumore mit Zytostatika ist oft eine Resistenzentwicklung zu verzeichnen, die ein Therapieversagen verursachen kann. Es ist bekannt, dass Tumorzellen oft einen veränderten Stoffwechsel besitzen. ... -
Analysis of the cAMP-regulated metabolome of skeletal muscle and adipose tissue
(2025-02-10)Aging, obesity and physical inactivity are three major risk factors leading to non-communicable diseases, like coronary heart disease or type 2 diabetes, resulting in reduced health and quality of life. As the number of ... -
The essential role of Cytohesin-2 as a regulator of intracellular transport
(2025-02-06)The protein family of cytohesins, comprising cytohesin-1 to -4, was identified between 1996 and 2000 as small guanine nucleotide exchange factors for ADP ribosylation factor (ARF) GTPases. Since then, the function of ... -
Boundary conditions and dynamics of fluvial obstacle mark formation
(2025-02-05)Obstacles like boulders, riparian vegetation, and man-made structures such as bridge piers are common in fluvial environments. When exposed to flow, they form characteristic geomorphological and sedimentary structures known ... -
Spatial Priors and Uncertainty for Enhanced Reconstruction in Computer Graphics and Vision
(2025-02-04)Many tasks in computer vision aim to reconstruct unknown quantities from observations of a scene, such as estimating depth from stereo vision, generating intermediate video frames, or revealing hidden shapes from transient ... -
Operationalizing Empathic and Supportive Communication in Natural Language Processing
(2025-02-04)Empathic communication is a significant aspect of support and health-oriented interactions. Theoretical models for clinical and counseling conversations outline its role in fostering open disclosure between patients and ... -
Towards High Precision Measurements of Higgs Boson Properties in the Di-Tau Decay with the ATLAS Detector
(2025-01-28)The Standard Model of particle physics (SM) describes the known fundamental particles and their interactions. The model is found to be incomplete with a need for extensions in order to cover all current experimental ... -
Cross-Lingual Ontology Matching and Enrichment
(2025-01-28)The Semantic Web has emerged as a foundational paradigm for representing and interlinking data in a semantically meaningful manner. Central to this paradigm are ontologies, pivotal for encapsulating spatial knowledge and ... -
Hordeum erectifolium, a physiological and genomic study of drought-adaptive traits
(2025-01-24)Drought stresses plants at multiple levels, affecting water uptake, stomatal evaporation, and intracellular stability, which in turn impacts plant fitness and yield. To develop climate-resilient crops, I investigated ... -
Compact Description for High Resolution Spatial Weather Extremes
(2025-01-22)Detecting local climate change signals, particularly within the context of extreme weather events, is challenging due to the significant internal variability of the climate system. This thesis, part of the BMBF-funded ... -
Dispersive analyses of three-body decays and scattering reactions
(2025-01-22)More than half a century after the discovery of quantum chromodynamics as the quantum-field-theoretical description of the strong interaction, its non-perturbative nature in the low-energy regime still poses a unique ... -
Synthese und Charakterisierung tetraederförmiger metallosupramolekularer Komplexe aus chromophoren Liganden
(2025-01-22)Die vorliegende Arbeit beschäftigt sich mit der Planung, Synthese und Charakterisierung von neuen tetraederförmigen metallosupramolekularen Käfigkomplexen, in welche insbesondere auf dem Chromophor Perylen aufbauende ... -
Development of Quantum Chemistry based Workflows for the Theoretical Description of Organic Electronics
(2025-01-21)Organic electronics (OE) have become increasingly significant in daily life. Groundbreaking inventions such as organic solar cells (OSCs), organic light-emitting diodes (OLEDs), and organic field-effect transistors (OFETs) ... -
Structural and Functional Characterization, Targeted Degradation, and Inhibition of Cyclin-dependent Kinases Involved in Transcriptional Regulation
(2025-01-21)Transcription-associated cyclin-dependent kinases (CDKs) are serine/threonine-directed kinases that, when activated by their corresponding cyclin subunits, play a crucial role in tightly regulating key transcriptional ... -
Hyperon Spectrum in a dynamical coupled-channel approach
(2025-01-20)In this study, we investigate the $bar{K}N$ reactions using a coupled-channels approach, covering the range of center of mass energies from the $bar{K}N$ threshold up to 2 GeV. We develop a dynamical coupled-channel model ...
