The Faculty of Mathematics and Natural Sciences: Mathematisch-Naturwissenschaftliche Fakultät: Recent submissions
Now showing items 41-60 of 4736
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Establishment of bioanalytical workflows for the quality assessment of formulated proteins
(2025-03-17)Proteins and peptides contribute to a significant class of therapeutic agents in the pharmaceutical market. Over the last decades, they gained growing interest due to their safety and specificity compared to small molecule ... -
Rab requirements in HOPS-mediated late endosome-lysosome tethering and dissection of fusion factor requirements in Ca2+-dependent phagosome-lysosome fusion
(2025-03-17)Through sequential fusion with early- and late endosomes (EEs and LEs) and ultimately lysosomes (LYS), a degradative (endo-)lysosome ((E)LYS is formed. Directionality of fusion is ensured by the action of Ras-like GTPases ... -
Transcriptomic heterogeneity of microglia in relation to Alzheimer's disease-associated pathology and post-mortem delay
(2025-03-17)(noch nicht zugänglich / not yet accessible) -
Advanced deep learning methods for quantifying imaging biomarkers in large cohort studies
(2025-03-14)Understanding the anatomical structures of the body and brain, and their influence on human health throughout the lifespan is of significant research and clinical interest. Tracking of structural changes can provide insights ... -
Multi-Person Pose Tracking in Videos
(2025-03-14)This thesis addresses the complex challenges of multi-person pose estimation and tracking in dynamic, real-world environments. Motivated by advancements in artificial intelligence and the growing need for natural human-machine ... -
Investigating the molecular mechanisms involved in the developmental assembly of the mushroom body calyx in Drosophila melanogaster
(2025-03-11)How a circuit functions can be investigated by examining the organisation of the circuit to be able to decipher the connectivity logic and the logic of information flow within that circuit. Hence, to understand how the ... -
Transverse Momentum Dependent Parton Distribution Functions from Twisted Mass Lattice QCD
(2025-03-09)The aim of this thesis is the theoretical calculation of the unpolarized transverse momentum dependent parton distribution function (TMDPDF) from first principles using lattice QCD. TMDPDFs are important quantities that ... -
Addressing Domain Shift in CNN-based Image Segmentation: From Improving Robustness to Unsupervised and Active Learning based Domain Adaptation
(2025-03-07)Pixel-wise labeling of images is a common task in applications nowadays as it allows humans and machines to make sense of the content in an image and informs their decisions about subsequent steps to be taken. Examples of ... -
Environmentally induced development of pulmonary monocyte-derived alveolar macrophages is controlled by Apolipoprotein E and Dectin-1
(2025-03-06)The lung is one of the largest barrier tissues of our body, and is constantly exposed to the environment. By inhaling, the lungs do not only take up oxygen, which is crucial for cellular respiration, but also a plethora ... -
Investigating Graphene-Based Systems: Interaction Effects, Localization, and Finite-Temperature Dynamics
(2025-03-05)This dissertation presents a comprehensive theoretical and numerical investigation into the electronic properties of graphene‐based systems, with a focus on interaction effects, localization phenomena, and finite‐temperature ... -
Ultracold fermions in periodically-driven superlattices
(2025-03-05)This thesis presents quantum simulation of strongly-correlated systems beyond standard Hubbard models, using ultracold fermionic potassium atoms in both static and periodically-driven optical superlattices. For this study, ... -
Efficient Prediction of Mole Fraction Related Vibrational Frequency Shifts
(2023-11-16)While so far it has been possible to calculate vibrational spectra of mixtures at a particular composition, we present here a novel cluster approach for a fast and robust calculation of mole fraction dependent infrared and ... -
A Quantum Cluster Equilibrium Theory for Multi-Component Liquids
(2024-02-19)In this work, we present a new theory to treat multi-component liquids based on quantum-chemically calculated clusters. The starting point is the binary quantum cluster equilibrium theory that is able to treat binary ... -
Adaptive Geospatial Data Representation for Data Analytics and Sharing in the Mobility Domain
(2025-02-25)In recent years, the mobility domain has gained attention from urban planners and researchers due to its essential role in enhancing urban safety and development. This interest can be attributed to the increased availability ... -
Development of the first geldanamycin-based HSP90 degraders
(2023-06-28)Despite the early clinical promise, adverse events such as acquired resistance and dose-limiting toxicities have barred the widespread use of HSP90 inhibitors as anticancer drugs. A new approach involving proteolysis-targeting ... -
A Systematic Database Approach to Identify Companion Diagnostic Testing in Clinical Trials under the New In Vitro Diagnostic Medical Devices Regulation
(2023-06-12)The European Union In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746 (IVDR) introduces companion diagnostics (CDx) as a new legal term. CDx are applied in combination with a medicinal product to identify patient ... -
Quantum optimal transport for AF-C*-algebras
(2025-02-14)We introduce quantum optimal transport of states on tracial AF-C*-algebras to study non-spatial transport of quantum information, and view it as the pointwise case of a general parametrised one. We define quantum optimal ... -
A Cell Panel to Characterise Tau Aggregation
(2025-02-13)(noch nicht zugänglich / not yet accessible) -
Betrachtung des Zellmetabolismus mit Fokus auf Hexokinase 2 und IGFBP-2 im Tumorresistenzgeschehen
(2025-02-11)Bei der Behandlung solider Tumore mit Zytostatika ist oft eine Resistenzentwicklung zu verzeichnen, die ein Therapieversagen verursachen kann. Es ist bekannt, dass Tumorzellen oft einen veränderten Stoffwechsel besitzen. ... -
Analysis of the cAMP-regulated metabolome of skeletal muscle and adipose tissue
(2025-02-10)(noch nicht zugänglich / not yet accessible)
