The Faculty of Mathematics and Natural Sciences: Mathematisch-Naturwissenschaftliche Fakultät: Recent submissions
Now showing items 741-760 of 5008
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Elucidating the Role of Long Noncoding RNA H19 in Aortic Valve Disease
(2024-02-02)Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and continue to be a major global health concern. Among various types of CVDs, calcific aortic valve disease (CAVD) has garnered significant ... -
Deep Generative Modelling in Systems Medicine: From Transcriptomics Data to Drug Development
(2024-02-02)Artificial intelligence (AI) has been widely applied across many domains, including the biomedical research field. These AI models mostly include discriminative models such as classifiers and regressors that predict for ... -
Towards a better understanding of neuron-NG2 glia signaling: Comparative studies in the hippocampus and cerebellum
(2024-02-01)Grey matter NG2 glia constitutes a heterogeneous glial population whose functions remain incompletely understood. Their ability to make synapses with neurons is unique among glial cells, but the purpose of these connections ... -
Comprehensive population synthesis predictions for massive binary stars in the Small Magellanic Cloud
(2024-01-30)The past and ongoing gravitational wave detections have fostered a wide interest in understanding the formation of binary black holes (BBHs). Several formation scenarios have been proposed, including the evolution of ... -
Functional characterization of Gαi/s proteins and modulation of their activity by linear and cyclic peptides
(2024-01-30)Heterotrimeric Gαβγ (guanine nucleotide-binding) proteins serve as molecular switches to activate (“switch on”) or inactivate (“switch off”) diverse intracellular signaling cascades in response to stimulated G protein-coupled ... -
Twisted ambidexterity in equivariant homotopy theory: Two approaches
(2024-01-30)This dissertation explores the phenomenon of twisted ambidexterity in equivariant stable homotopy theory for compact Lie groups, which encompasses, and sheds a new light on, equivariant Atiyah duality and the Wirthmüller ... -
Non-Reversible Markov-Chain Monte Carlo: Theoretical Foundations and Applications in Molecular Simulation
(2024-01-29)The overarching objective of this doctoral thesis is the development of a rigorous paradigm for molecular simulation based on non-reversible Markov-chain Monte Carlo (MCMC) algorithms. The numerical exploration of the ... -
Pulsar Scintillation and Interstellar Lenses
(2024-01-29)The radio emission of pulsars is scattered within the interstellar medium due to variations of the electron column density. Pulsars are very compact sources of pulsed radiation and, thus, emit spatially coherent radiation ... -
Evaluation of permeation of active pharmaceutical ingredients through outer biological barriers for topical application
(2024-01-29)The pharmaceutical therapy of diseases and health conditions is mostly connected to a systemic application of drug substances, most commonly in the form of solid dosage forms for oral application in order to reach their ... -
Enzymatische Herstellung und Reinigung von Fructooligosacchariden des Inulin-Typs und deren Verwertung durch abundante Darmbakterien
(2024-01-24)Fructooligosaccharide vom Inulin-Typ (I-FOS) sind präbiotische Fructan-Oligomere, die hauptsächlich aus ß-(2,1)-verknüpften Fructose-Einheiten bestehen. I-FOS haben aufgrund ihrer gesundheitsfördernden Wirkung und funktionellen ... -
Time-Resolved Spectroscopy of Transition Metal Complexes
(2024-01-23)Owing to their thermodynamic properties, transition metal azido compounds are often prone to decomposition. Frequently, this occurs under release of dinitrogen giving rise to nitrene or nitride complexes which are of ... -
ESCRT in der Makrophageninfektion durch Rhodococcus equi
(2024-01-22)Das Gram-positive Bakterium <em>Rhodococcus equi</em> (<em><em>R. equi</em></em>) ist ein fakultativ intrazelluläres Lungenpathogen bei Pferdefohlen, aber auch gefährlich für immunkomprimierte Menschen. Sein Schlüssel zur ... -
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
(2024-01-22)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ... -
Benthic foraminifera as proxies to infer paleoenvironmental conditions: Case studies from Western Siberia, and the Arabian and Mediterranean Sea
(2024-01-22)Foraminifera are among the most important microfossils and invaluable tools for geosciences. Because of their small size and abundance, foraminifera are widely involved in applied studies where they are used for age-dating, ... -
pH Regulation in Human Sperm
(2024-01-18)In the female reproductive tract, sperm undergo a maturation process, called capacitation, which enables sperm to fertilize the oocyte. The complex cellular mechanisms underlying capacitation are not well understood. Besides ... -
Katalytische Reaktionen auf VO2-Polymorph Oberflächen unter Ausnutzung des Phasenübergangs
(2024-01-17)Aufgrund des wachsenden Energiebedarfs der Menschheit werden energieeffizientere und neuartige Verfahren zur Herstellung von chemischen Grundstoffen mithilfe von Katalyse gesucht. Fluktuierende Reaktionsbedingungen werden ... -
Stability of dynamics and memory in the balanced state
(2024-01-17)Computational modeling of neural circuits has successfully explained the observed irregular and asynchronous activity in the brain as the result of a dynamical balance of excitatory and inhibitory inputs to individual ... -
Improved Approximation Algorithms for Weighted k-Set Packing
(2024-01-16)We study the weighted k-Set Packing problem, which is defined as follows: The input consists of a finite collection S of non-empty sets, each of cardinality at most k, as well as a positive weight for each of the sets. The ... -
Quantum Simulation of the Periodic Quantum Rabi Model at Deep Strong Coupling
(2024-01-16)The quantum Rabi model (QRM) stands as perhaps the most fundamental framework describing qubit-light interaction. While observations of many experiments can already be described within the Jaynes-Cummings model, which ... -
Utilizing Constrained Homomorphisms in the Design of Efficient Graph Kernels
(2024-01-16)Learning on graphs, particularly graph classification, requires rich graph representations. A common paradigm to obtain these is by extracting sets of substructures and representing graphs by such sets. The obtained graph ...
