Mathematisch-Naturwissenschaftliche Fakultät: Mathematisch-Naturwissenschaftliche Fakultät: Neuzugänge
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Machine learning approaches for adaptive optics in microscopy
(2023-05-08)Microscopic imaging is an essential tool for science. For instruments that operate close to the physically possible diffraction limit, a main remaining challenge are aberrating operating conditions. For microscopy, such ... -
Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer Therapy
(2023-02-25)Histone deacetylases (HDACs) play a key role in the control of transcription, cell prolifer- ation, and migration. FDA-approved histone deacetylase inhibitors (HDACi) demonstrate clinical efficacy in the treatment of ... -
Efficient geomorphological mapping based on geographic information systems and remote sensing data: an example from Jena, Germany
(2023-03-06)We present a detailed geomorphological map (1:5000-scale) of a middle mountainous area in Jena, Germany. To overcome limitations and to extend the possibility of manually digital mapping in a structural way, we propose an ... -
Modular q–difference equations and quantum invariants of hyperbolic three–manifolds
(2023-04-28)In this thesis, we take up the study of quantum invariants of hyperbolic closed three manifolds. In particular, we consider the behaviour of the Witten-Reshetikhin-Turaev invariants associated to the Lie algebra of the ... -
Lipid II-binding antibiotics – differential antibiotic activities beyond sequestration of the central peptidoglycan precursor
(2023-04-28)Antibiotic resistance has reached crisis proportions and is a leading mortality factor worldwide. Despite the relevance for public health globally, the antibiotic-discovery pipeline is drying up. The reason for the steep ... -
Irreversible Antagonists for the Adenosine A2B Receptor
(2022-06-13)Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based ... -
Symptom burden in cancer patients: Evaluation of medication risks and development of disease-specific PRO instruments
(2023-04-27)In oncology, adverse events are usually documented using the Common Terminology Criteria for Adverse Events (CTCAE). This physician-reported assessment can be supported by patient-reported outcomes (PRO) that play an ... -
Neuroanatomie und Funktionsmorphologie Peripherer Rezeptorneurone mit Direkten Projektionen in das Protocerebrum des Insektengehirns
(2023-04-20)Zur Wahrnehmung unterschiedlicher thermischer Reize hat sich bei Insekten eine Reihe von Thermorezeptoren entwickelt. Der pyrophile („feuerliebend“) „Australische Feuerkäfer“ (<em>Merimna atrata</em>) besitzt paarige ... -
On Modeling and Assessing Uncertainty Estimates in Neural Learning Systems
(2023-04-20)While neural networks are universal function approximators when looked at from a theoretical perspective, we face, in practice, model size constraints and highly sparse data samples from open-world contexts. These limitations ... -
Measurements of the mass and width of the W-boson, and test of lepton universality in W-boson decays with the ATLAS detector
(2023-04-20)The Standard Model of particle physics serves as the predominant theory of the microscopic world for many decades. Many discoveries have been predicted by this model and it still provides a good fit for a wide variety of ... -
Next-Generation Electronics for the Read-Out of Micro-Pattern Gaseous Detectors
(2023-04-20)Developed by the RD51 collaboration, the Scalable Readout System (SRS) is widely used for the read-out of Micro-Pattern Gaseous Detectors (MPGDs). With different front-end Application-Specific Integrated Circuits (ASICs) ... -
Ectopic expression of transcription factors to overcome the lineage barrier between embryonic stem cells and trophoblast stem cells in mouse and human
(2023-04-19)The placenta is a transient organ that exhibits various essential functions during pregnancy that allow for proper development of the embryo. Placenta and embryo originate from the first lineage separation in mammalian ... -
GPR183 controls spatial organization and survival of hepatic conventional dendritic cells within hepatic portal regions via M-CSF and Gas6
(2023-04-19)G protein-coupled receptor 183 (GPR183) recognizes 7α,25-dihydroxycholesterol (7α,25-OHC) and exerts chemotactic action upon recognition. Recent studies have shown that GPR183 is highly expressed in T, B and dendritic cells ... -
Enantioselektive Totalsynthese von (+)-Salimabromid und Studien zur Synthese von Acyldepsipeptiden
(2023-04-19)<strong>Salimabromid</strong> <br /> Das aus dem marinen Myxobakterium, <em>Enhygromyxa salina</em>, isolierte Polyketid, Salimabromid, wurde mit seinem neuartigen Kohlenstoffgerüst in einer enantioselektiven ... -
Weiterentwicklung und Optimierung der Kontrolle der geschlossenen Gleichgewichtsbahn und des Modells der Elektronen-Stretcher-Anlage ELSA
(2023-04-17)An der Beschleunigeranlage ELSA am Physikalischen Institut der Universität Bonn werden gegenwärtig zwei Experimente betrieben, welche die innere Struktur der Nukleonen untersuchen. ELSA zeichnet sich insbesondere durch die ... -
Evaluation of Striatin as a novel Microtubule Modulator
(2023-04-13)The dynamics of the cell cycle and cell division are governed by tubulin polymers, <em>i. e.</em> microtubules (MTs). Defects of MT assembly or disassembly lead to pathogenic cellular conditions, negatively affecting cell ... -
Hadrons in a finite volume and in a background field
(2023-04-13)In this cumulative thesis, we study various properties of hadrons in a finite volume. The motivation of this work is the following: The Quantum Chromodynamics (QCD) is a fundamental theory describing hadrons. The crucial ... -
Interaktion und neuronanatomische Grundlagen des elektrosensorischen und visuellen Systems während der multimodalen Objekterkennung: Die dynamische Gewichtung der einzelnen Sinne in Abhängigkeit ihrer Verlässlichkeit und sensorischer Vorerfahrungen beim schwach elektrischen Fisch Gnathonemus petersii
(2023-04-05)Während der Interaktion mit der Umwelt nehmen Organismen mit den Sinnessystemen unterschiedlichste sensorische Informationen wahr. Beim Menschen wurde gezeigt, dass der multimodale Eingang während der Integration dynamisch ... -
Direkte pharmakologische Gq-Protein-Modulation in pulmonalen Gefäßen
(2023-04-04)Heterotrimere G-Proteine können in vier Familien entsprechend ihrer alpha-Untereinheit unterteilt werden (Gs, Gi, G12/13 und Gq). Sie überführen ein extrazelluläres Signal nach der Aktivierung von G-Protein-gekoppelten ... -
Klima und Ernteertrag: eine statistische Analyse an ausgewählten Beispielen nord- und südsaharischer Trockenräume - Senegal, Sudan, Tunesien
(1989)Die vorliegende Studie greift ein Problem auf, das erstmals zum Ende der sechziger Jahre und zu Beginn der siebziger wieder stärker in das allgemeine Bewußtsein eingegangen ist: die große „Sahel-Dürre“, die damals nahezu ...
