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Oxytocin – the prosocial molecule?
Intranasal oxytocin effects on social approach behavior, social cognition, volitional and emotional ambivalence in healthy human beings

dc.contributor.advisorHurlemann, René
dc.contributor.authorPreckel, Katrin
dc.date.accessioned2020-04-21T10:01:21Z
dc.date.available2020-04-21T10:01:21Z
dc.date.issued30.10.2015
dc.identifier.urihttps://hdl.handle.net/20.500.11811/6548
dc.description.abstractOxytocin (OXT) is a highly conserved neuropeptide, regarding both its chemical structure and its functionality. It has been traced back at least 700 million years. OXT’s fundamental role lies in reproduction and parenting behavior. OXT findings in animal models, which provided the initial interest for OXT research in humans, are presented in this thesis to clarify the importance of biochemical mechanisms, sexual-dimorphism and species-specificity of the OXT system. In the past few years, OXT has become a very prominent molecule because it may improve social deficits, even in psychiatric illnesses, e.g. social phobia or schizophrenia. However, past research findings have produced highly controversial results in regard to OXT’s prosocial role, which might also be due to the complexity of the biochemical mechanisms which are still widely unknown. This dissertation examines modulatory influences of intranasal OXT on different social domains in healthy women and men to further distinguish the prosocial – and possibly beneficial – effects of this neuropeptide. The first study revealed prosocial effects of intranasal OXT in women, who selectively approached social positive stimuli quicker and more closely after OXT administration. In the second study, OXT was also found to have a prosocial effect. It increased the willingness to induce happy emotions, while it reduced the willingness to induce anger or fear. The willingness to induce positive, but not negative emotions, was accompanied by (for example) reduced or increased inferior frontal gyurs (IFG) activity, respectively. In the third study, OXT was indirectly investigated as a prosocial neuropeptide. The fMRI study revealed that OXT diminished neural activity in the dorsal anterior cingulate cortex (dACC) in response to volitional (Experiment 1) as well as emotional (Experiment 2) ambivalence. Behaviorally, the OXT effect was apparent in faster reaction times (Experiment 1) and reduced arousal ratings (Experiment 2). In conclusion, the results of the three presented studies indicate that OXT does primarily act as a prosocial molecule, however the prosocial tendencies of OXT may be tilted by many different moderators such as genetic predispositions, early life experiences or strong personality traits.
dc.language.isoeng
dc.rightsIn Copyright
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subject.ddc540 Chemie
dc.subject.ddc570 Biowissenschaften, Biologie
dc.subject.ddc590 Tiere (Zoologie)
dc.subject.ddc610 Medizin, Gesundheit
dc.titleOxytocin – the prosocial molecule?
dc.title.alternativeIntranasal oxytocin effects on social approach behavior, social cognition, volitional and emotional ambivalence in healthy human beings
dc.typeDissertation oder Habilitation
dc.publisher.nameUniversitäts- und Landesbibliothek Bonn
dc.publisher.locationBonn
dc.rights.accessRightsopenAccess
dc.identifier.urnhttps://nbn-resolving.org/urn:nbn:de:hbz:5n-41630
ulbbn.pubtypeErstveröffentlichung
ulbbnediss.affiliation.nameRheinische Friedrich-Wilhelms-Universität Bonn
ulbbnediss.affiliation.locationBonn
ulbbnediss.thesis.levelDissertation
ulbbnediss.dissID4163
ulbbnediss.date.accepted21.08.2015
ulbbnediss.instituteMedizinische Fakultät / Kliniken : Klinik für Psychiatrie und Psychotherapie
ulbbnediss.fakultaetMathematisch-Naturwissenschaftliche Fakultät
dc.contributor.coRefereeBleckmann, Horst


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