Steep, Spatially Graded Recruitment of Feedback Inhibition by Sparse Dentate Granule Cell Activity
Steep, Spatially Graded Recruitment of Feedback Inhibition by Sparse Dentate Granule Cell Activity
dc.contributor.advisor | Beck, Heinz | |
dc.contributor.author | Braganza, Oliver | |
dc.date.accessioned | 2020-04-22T01:41:17Z | |
dc.date.available | 2020-04-22T01:41:17Z | |
dc.date.issued | 24.05.2016 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11811/6761 | |
dc.description.abstract | The dentate gyrus of the hippocampus is thought to subserve important physiological functions, such as 'pattern separation'. In chronic temporal lobe epilepsy, the dentate gyrus constitutes a strong inhibitory gate for the propagation of seizure activity into the hippocampus proper. Both examples are thought to depend critically on a steep recruitment of feedback inhibition by active dentate granule cells. Here, I used two complementary experimental approaches to quantitatively investigate the recruitment of feedback inhibition in the dentate gyrus. I showed that the activity of approximately 4% of granule cells suffices to recruit maximal feedback inhibition within the local circuit. Furthermore, the inhibition elicited by a local population of granule cells is distributed non-uniformly over the extent of the granule cell layer. Locally and remotely activated inhibition differ in several key aspects, namely their amplitude, recruitment, latency and kinetic properties. Finally, I show that net feedback inhibition facilitates during repetitive stimulation. Taken together, these data provide the first quantitative functional description of a canonical feedback inhibitory microcircuit motif. They establish that sparse granule cell activity, within the range observed in-vivo, steeply recruits spatially and temporally graded feedback inhibition. | en |
dc.language.iso | eng | |
dc.rights | In Copyright | |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
dc.subject | Rückkoppelnde Hemmung | |
dc.subject | Gyrus Dentatus | |
dc.subject | Hippocampus | |
dc.subject | Mikronetzwerk Motif | |
dc.subject | feedback inhibition | |
dc.subject | microcircuit motif | |
dc.subject.ddc | 500 Naturwissenschaften | |
dc.title | Steep, Spatially Graded Recruitment of Feedback Inhibition by Sparse Dentate Granule Cell Activity | |
dc.type | Dissertation oder Habilitation | |
dc.publisher.name | Universitäts- und Landesbibliothek Bonn | |
dc.publisher.location | Bonn | |
dc.rights.accessRights | openAccess | |
dc.identifier.urn | https://nbn-resolving.org/urn:nbn:de:hbz:5n-43501 | |
ulbbn.pubtype | Erstveröffentlichung | |
ulbbnediss.affiliation.name | Rheinische Friedrich-Wilhelms-Universität Bonn | |
ulbbnediss.affiliation.location | Bonn | |
ulbbnediss.thesis.level | Dissertation | |
ulbbnediss.dissID | 4350 | |
ulbbnediss.date.accepted | 20.04.2016 | |
ulbbnediss.institute | Medizinische Fakultät / Kliniken : Klinik für Epileptologie | |
ulbbnediss.fakultaet | Mathematisch-Naturwissenschaftliche Fakultät | |
dc.contributor.coReferee | Pankratz, Michael |
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