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Steep, Spatially Graded Recruitment of Feedback Inhibition by Sparse Dentate Granule Cell Activity

dc.contributor.advisorBeck, Heinz
dc.contributor.authorBraganza, Oliver
dc.date.accessioned2020-04-22T01:41:17Z
dc.date.available2020-04-22T01:41:17Z
dc.date.issued24.05.2016
dc.identifier.urihttp://hdl.handle.net/20.500.11811/6761
dc.description.abstractThe dentate gyrus of the hippocampus is thought to subserve important physiological functions, such as 'pattern separation'. In chronic temporal lobe epilepsy, the dentate gyrus constitutes a strong inhibitory gate for the propagation of seizure activity into the hippocampus proper. Both examples are thought to depend critically on a steep recruitment of feedback inhibition by active dentate granule cells. Here, I used two complementary experimental approaches to quantitatively investigate the recruitment of feedback inhibition in the dentate gyrus. I showed that the activity of approximately 4% of granule cells suffices to recruit maximal feedback inhibition within the local circuit. Furthermore, the inhibition elicited by a local population of granule cells is distributed non-uniformly over the extent of the granule cell layer. Locally and remotely activated inhibition differ in several key aspects, namely their amplitude, recruitment, latency and kinetic properties. Finally, I show that net feedback inhibition facilitates during repetitive stimulation. Taken together, these data provide the first quantitative functional description of a canonical feedback inhibitory microcircuit motif. They establish that sparse granule cell activity, within the range observed in-vivo, steeply recruits spatially and temporally graded feedback inhibition.
dc.language.isoeng
dc.rightsIn Copyright
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectRückkoppelnde Hemmung
dc.subjectGyrus Dentatus
dc.subjectHippocampus
dc.subjectMikronetzwerk Motif
dc.subjectfeedback inhibition
dc.subjectmicrocircuit motif
dc.subject.ddc500 Naturwissenschaften
dc.titleSteep, Spatially Graded Recruitment of Feedback Inhibition by Sparse Dentate Granule Cell Activity
dc.typeDissertation oder Habilitation
dc.publisher.nameUniversitäts- und Landesbibliothek Bonn
dc.publisher.locationBonn
dc.rights.accessRightsopenAccess
dc.identifier.urnhttps://nbn-resolving.org/urn:nbn:de:hbz:5n-43501
ulbbn.pubtypeErstveröffentlichung
ulbbnediss.affiliation.nameRheinische Friedrich-Wilhelms-Universität Bonn
ulbbnediss.affiliation.locationBonn
ulbbnediss.thesis.levelDissertation
ulbbnediss.dissID4350
ulbbnediss.date.accepted2016-04-20
ulbbnediss.instituteMedizinische Fakultät / Kliniken : Klinik für Epileptologie
ulbbnediss.fakultaetMathematisch-Naturwissenschaftliche Fakultät
dc.contributor.coRefereePankratz, Michael


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