Kliniken: Kliniken: Recent submissions
Now showing items 1-20 of 79
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Fibroblast growth factor receptor 2 (FGFR2) genetic polymorphisms contribute to fused roots in human molars
(2025-04-10)Fibroblast growth factors (FGFRs) signaling are required for human tooth development. Its dysregulation affects tooth formation and patients with <em>FGFR2</em> mutations often present dental anomalies in the spectrum of ... -
The PJI-TNM Classification as Predictor for Revision-Free Implant Survival Rates in Patients with Periprosthetic Joint Infection of the Hip or Knee Joint
(2025-05-15)Background: Periprosthetic joint infections (PJIs) remain a major challenge in arthroplasty. This study tries to evaluate the PJI-TNM classification as predictor for the revision-free implant survival in patients with PJI ... -
Intraoperative Profiling of the Supracrestal Implant Complex Minimizes Peri-Implant Crestal Bone Remodeling: The Guided Bone Profiling Concept
(2025-03-08)(1) Background: Early-stage bone resorption following implant placement can significantly impact the long-term success of implants. This study evaluates whether a fully digitally planned implant position based on the E-point ... -
Trajectories of Mental Distress and Resilience During the COVID-19 Pandemic Among Healthcare Workers
(2025-03-06)<strong>Background/Objectives:</strong> The recent COVID-19 pandemic posed a significant psychological challenge for healthcare workers. Resilience and the extent of psychological stress varied across professional groups ... -
Investigating the impact of polymorphisms in the ANKK1 and DRD2 genes on oral health-related quality of life in male patients with temporomandibular disorders
(2025-06-20)<strong>Introduction:</strong> Previous studies have reported that genetic polymorphisms may impact the signs and symptoms of temporomandibular disorder (TMD). Therefore, this study aimed to investigate the association ... -
Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness
(2025-02-20)<strong>Background: </strong>Asthma is associated with atherosclerosis and abdominal aortic aneurysm (AAA). However, the underlying pathomechanisms remain elusive. Blood eosinophil count (BEC) is implicated in both ... -
Beneficial effects of non-invasive physical plasma on human periodontal ligament cells in vitro
(2024-11-19)<strong>Introduction:</strong> Periodontitis is a chronic inflammatory disease of the periodontium that can lead to the loss of affected teeth if left untreated. It is induced by a multifactorial process centered on microbial ... -
First-Line Treatment for Advanced Hepatocellular Carcinoma: A Three-Armed Real-World Comparison
(2024-01-13)<strong>Background and Aim:</strong> There are several existing systemic 1st- line therapies for advanced hepatocellular carcinoma (HCC), including atezolizumab/bevacizumab (Atez/Bev), sorafenib and lenvatinib. This study ... -
IL-6–Dependent STAT3 Activation and Induction of Proinflammatory Cytokines in Primary Sclerosing Cholangitis
(2023-06-01)<strong>INTRODUCTION: </strong>Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease with periductal inflammation and fibrosis. Genetic studies suggest inflammatory cytokines and IL-6–dependent activation ... -
Impaired immunogenicity after vaccination for SARS-CoV-2 in patients with gastrointestinal cancer: does tumor entity matter?
(2023-06-26)<strong>Background:</strong> SARS-CoV-2 immunogenicity in patients with gastrointestinal cancer (GI cancer) following second and third vaccination was analyzed.<br /> <strong>Methods:</strong> A total of 125 patients under ... -
IDEAL–compliant implementation of the Dexter® surgical robot in cholecystectomy: A comprehensive framework and clinical outcomes
(2024-12-30)<strong>Objectives:</strong> The integration of advanced technologies is transforming surgical practice, particularly through robotic systems. This study presents the early clinical implementation of the Dexter<sup>®</sup> ... -
Longitudinal Study of SARS-CoV-2 Vaccinations and Infections in Patients with Gastrointestinal Cancer: Stabilizing Immune Responses and Neutralizing Emerging Variants with Variant-Adapted Antigen Exposures
(2024-12-19)This longitudinal study examined how active gastrointestinal (GI) cancer types affect immune responses to SARS-CoV-2, focusing on the ability to neutralize the Omicron variants. Patients with GI cancer (<em>n</em> = 168) ... -
Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma
(2023-10-17)<strong>Background & Aims:</strong> Vaccination with tumor-associated antigen-pulsed dendritic cells leads to specific T-cell response against hepato-cellular carcinoma. However, clinical response has been shown to be ... -
Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years
(2024-04-30)<strong>PURPOSE.</strong> To longitudinally assess the impact of high-risk structural biomarkers for natural disease progression in non-exudative age-related macular degeneration (AMD) on spatially resolved mesopic and ... -
The Spectrum of Functional, Structural and Patient-Reported Outcomes in Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report
(2025-02-03)<em><strong>Introduction:</strong></em> There is an unmet medical need for therapies in intermediate age-related macular degeneration (iAMD). The prospective European multi-center cohort study MACUSTAR validates structural, ... -
Comparative Analysis of Shear Bond Strength in Orthodontic Brackets Between Milled and 3D-Printed Definitive CAD/CAM Restorations
(2024-10-18)<strong>Objective:</strong> The objective of this study was to evaluate the effect of different surface treatment methods on the shear bond strength (SBS) of metal brackets bonded to two types of CAD/CAM composite restorations: ... -
Single-neuron representations of odours in the human brain
(2024-10-09)Olfaction is a fundamental sensory modality that guides animal and human behaviour. However, the underlying neural processes of human olfaction are still poorly understood at the fundamental—that is, the single-neuron—level. ... -
Microbial Spectrum, Intraoperative Findings, and Postoperative Outcomes in Native Knee Joint Infections: A Retrospective Analysis
(2024-12-16)<strong>Background:</strong> Native knee joint infections, while uncommon, present a serious condition predominantly instigated by bacteria such as <em>Staphylococcus aureus</em>. Without timely intervention, they can ... -
From Language Models to Medical Diagnoses: Assessing the Potential of GPT-4 and GPT-3.5-Turbo in Digital Health
(2024-12-02)Background: Large language models (LLMs) like GPT-3.5-Turbo and GPT-4 show potential to transform medical diagnostics through their linguistic and analytical capabilities. This study evaluates their diagnostic proficiency ... -
Characterization of the disorganization of the inner retinal layers in diabetics using increased axial resolution optical coherence tomography
(2025-01-13)<strong>Purpose:</strong> To compare a novel high-resolution optical coherence tomography (OCT) with improved axial resolution (High-Res OCT) with conventional spectral-domain OCT (SD-OCT) with regard to their capacity to ...
