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Post-Surgical Outcomes of Kidney-Sparing Surgery vs. Radical Nephroureterectomy for Upper-Tract Urothelial Cancer in a Propensity-Weighted Cohort
(2025-08-25)Objectives: In localized upper-tract urothelial carcinoma (UTUC), radical nephroureterectomy (RNU) represents the surgical gold standard, but kidney-sparing surgery (KSS) offers an alternative. The surgical perspective, ... -
Evaluating Sorafenib (SORA-2) as Second-Line Treatment for Unresectable Hepatocellular Carcinoma: A European Retrospective Multicenter Study
(2025-03-13)Background/Objectives: Systemic treatment for unresectable hepatocellular carcinoma (HCC) has rapidly advanced, with immune checkpoint inhibitors now the preferred first-line option. However, with multiple agents available ... -
In Vivo Cone Photoreceptor Topography of the Human Foveola
(2025-08-06)<strong>PURPOSE.</strong> To study in vivo cone topography of the normal human foveola. <br/> <strong>METHODS.</strong> The fovea in both eyes of 30 healthy participants was imaged with adaptive optics scanning light ... -
Mesiodistal width correlation between primary and successor mandibular teeth: implication for early orthodontic diagnosis
(2025-09-24)<strong>Background:</strong> Most studies on permanent tooth width prediction focus on the predictive value of permanent teeth, however only a few studies examine the predictive value of primary teeth. The aim of this study ... -
Missing images: autobiographical memory in Aphantasia and blindness
(2025-09-11)Mental visual imagery, especially the ability to construct naturalistic scenes seems central to vivid episodic autobiographical memory (AM). This mini review will first highlight the neural anatomy of different aspects of ... -
Microbiological Profiles of Patients with Acute Periprosthetic Joint Infection Undergoing Debridement, Antibiotics, Irrigation and Implant Retention (DAIR)
(2025-08-30)<strong>Background:</strong> Periprosthetic joint infection (PJI) is one of the most serious complications following total joint arthroplasty. The debridement, antibiotics, irrigation, and implant retention (DAIR) procedure ... -
Passive Blood-Flow-Restriction Exercise's Impact on Muscle Atrophy Post-Total Knee Replacement: A Randomized Trial
(2025-07-23)<strong>Background/Objectives:</strong> Total knee arthroplasty (TKA) is commonly associated with postoperative muscle atrophy and weakness, while traditional rehabilitation is often limited by pain and patient compliance. ... -
In Vivo Antibiotic Elution and Inflammatory Response During Two-Stage Total Knee Arthroplasty Revision: A Microdialysis Pilot Study
(2025-07-24)<strong>Introduction: </strong>Two-stage revision with an antibiotic-loaded, temporary static cement spacer is a common treatment for periprosthetic joint infection (PJI) of the knee. However, limited data exists on in ... -
Peritonsillar abscess in children: A retrospective analysis on surgical and antimicrobial approaches
(2025-07-07)<strong>Background</strong> <br/> Peritonsillar abscess (PTA) is a prevalent infection for specialists in otorhinolaryngology and pediatric primary care providers, that has the potential to cause severe complications. ... -
Cognitive deficits in treatment-resistant depression: protocol for a systematic review and meta-analysis
(2025-07-03)<strong>Introduction</strong> Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often ... -
Phytochemical combinations of lichen Evernia prunastri (L.) Ach. reduce drug resistance to temozolomide but not to paclitaxel in vitro
(2025-09-15)<strong>Introduction:</strong> Temozolomide (TMZ) and Paclitaxel (PXT), crucial anti-cancer drugs for glioblastoma (GBM) and primary breast cancer (BC), respectively, face drug resistance. Therefore, we investigated the ... -
Evaluating the accuracy of generative artificial intelligence models in dental age estimation based on the Demirjian's method
(2025-07-29)<strong>Introduction:</strong> Dental age estimation plays a key role in forensic identification, clinical diagnosis, treatment planning, and prognosis in fields such as pediatric dentistry and orthodontics. Large language ... -
AI-Enhanced 3D Models in Global Virtual Reality Case Conferences for Surgical Care in a Low-Income Country: Exploratory Study
(2025-08-18)<strong>Background: </strong>Approximately 5 billion people worldwide lack adequate access to surgical care, primarily in the Global South. Especially in crisis regions and war zones, telemedical applications may enhance ... -
Quantitative and qualitative tremor evaluation after MR-guided focused ultrasound thalamotomy
(2025-05-02)<strong>Introduction:</strong> Tremor syndromes are common neurological disorders, usually distinguished by clinical examination. Ordinal rating scales are widely used to rate tremor severity but are limited by subjective ... -
A new generation of patient-reported outcome measures with large language models
(2025-03-24)<strong>Background</strong> Patient-reported outcome measures (PROMs) are cornerstones of patient-centered clinical medicine and reflect patients' abilities, difficulties, perceptions and behaviors. The highly structured ... -
Fibroblast growth factor receptor 2 (FGFR2) genetic polymorphisms contribute to fused roots in human molars
(2025-04-10)Fibroblast growth factors (FGFRs) signaling are required for human tooth development. Its dysregulation affects tooth formation and patients with <em>FGFR2</em> mutations often present dental anomalies in the spectrum of ... -
The PJI-TNM Classification as Predictor for Revision-Free Implant Survival Rates in Patients with Periprosthetic Joint Infection of the Hip or Knee Joint
(2025-05-15)Background: Periprosthetic joint infections (PJIs) remain a major challenge in arthroplasty. This study tries to evaluate the PJI-TNM classification as predictor for the revision-free implant survival in patients with PJI ... -
Intraoperative Profiling of the Supracrestal Implant Complex Minimizes Peri-Implant Crestal Bone Remodeling: The Guided Bone Profiling Concept
(2025-03-08)(1) Background: Early-stage bone resorption following implant placement can significantly impact the long-term success of implants. This study evaluates whether a fully digitally planned implant position based on the E-point ... -
Trajectories of Mental Distress and Resilience During the COVID-19 Pandemic Among Healthcare Workers
(2025-03-06)<strong>Background/Objectives:</strong> The recent COVID-19 pandemic posed a significant psychological challenge for healthcare workers. Resilience and the extent of psychological stress varied across professional groups ... -
Investigating the impact of polymorphisms in the ANKK1 and DRD2 genes on oral health-related quality of life in male patients with temporomandibular disorders
(2025-06-20)<strong>Introduction:</strong> Previous studies have reported that genetic polymorphisms may impact the signs and symptoms of temporomandibular disorder (TMD). Therefore, this study aimed to investigate the association ...
