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IDEAL–compliant implementation of the Dexter® surgical robot in cholecystectomy: A comprehensive framework and clinical outcomes
Dohmen, Jonas; Weber, Julia; Arensmeyer, Jan; Feodorovici, Philipp; Henn, Jonas; Schmidt, Joachim; Kalff, Jörg C.; Matthaei, Hanno (2024-12-30)<strong>Objectives:</strong> The integration of advanced technologies is transforming surgical practice, particularly through robotic systems. This study presents the early clinical implementation of the Dexter<sup>®</sup> ... -
Longitudinal Study of SARS-CoV-2 Vaccinations and Infections in Patients with Gastrointestinal Cancer: Stabilizing Immune Responses and Neutralizing Emerging Variants with Variant-Adapted Antigen Exposures
Gonzalez-Carmona, Maria A.; Schmitz, Alina M.; Berger, Moritz; Baier, Leona I.; Gorny, Jens G.; Sadeghlar, Farsaneh; Anhalt, Thomas; Zhou, Xin; Zhou, Taotao; Mahn, Robert; Möhring, Christian; Linnemann, Thomas; Schmid, Matthias; Strassburg, Christian P.; Boesecke, Christoph; Rockstroh, Jürgen K.; Eis-Hübinger, Anna-Maria; Monin, Malte B. (2024-12-19)This longitudinal study examined how active gastrointestinal (GI) cancer types affect immune responses to SARS-CoV-2, focusing on the ability to neutralize the Omicron variants. Patients with GI cancer (<em>n</em> = 168) ... -
Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma
Sadeghlar, Farsaneh; Seelemann, Julia; Vogt, Annabelle; Möhring, Christian; Zhou, Taotao; Mahn, Robert; Kornek, Miroslaw; Lukacs-Kornek, Veronika; Casares, Noelia; Lasarte, Juan José; Sarobe, Pablo; Beekum, Cornelius van; Matthaei, Hanno; Manekeller, Steffen; Kalff, Jörg; Schmidt-Wolf, Ingo G.H.; Strassburg, Christian P.; Gonzalez-Carmona, Maria A. (2023-10-17)<strong>Background & Aims:</strong> Vaccination with tumor-associated antigen-pulsed dendritic cells leads to specific T-cell response against hepato-cellular carcinoma. However, clinical response has been shown to be ... -
Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years
Saßmannshausen, Marlene; Döngelci, Senem; Vaisband, Marc; Emde, Leon von der; Sloan, Kenneth R.; Hasenauer, Jan; Holz, Frank G.; Schmitz-Valckenberg, Steffen; Ach, Thomas (2024-04-30)<strong>PURPOSE.</strong> To longitudinally assess the impact of high-risk structural biomarkers for natural disease progression in non-exudative age-related macular degeneration (AMD) on spatially resolved mesopic and ... -
The Spectrum of Functional, Structural and Patient-Reported Outcomes in Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report
Terheyden, Jan Henrik; Holz, Frank G.; Behning, Charlotte; Dunbar, Hannah M.P.; Schmitz-Valckenberg, Steffen; Tufail, Adnan; Schmid, Matthias; Crabb, David P.; Saßmannshausen, Marlene; Binns, Alison; Hoyng, Carel B.; Zakaria, Nadia; Poor, Stephen; Moll, Klaus-Peter; Cosette, Deborah; Martinho, Cecília; Batuca, Joana; Cunha-Vaz, José; Luhmann, Ulrich F.O.; Leal, Sergio; Finger, Robert P. (2025-02-03)<em><strong>Introduction:</strong></em> There is an unmet medical need for therapies in intermediate age-related macular degeneration (iAMD). The prospective European multi-center cohort study MACUSTAR validates structural, ... -
Comparative Analysis of Shear Bond Strength in Orthodontic Brackets Between Milled and 3D-Printed Definitive CAD/CAM Restorations
Aldosari, Mohammad A.; Anany, Noha M.; Alaqeely, Razan; Alsenaidi, Jawaher; Sufyan, Aref; Talaat, Sameh; Bourauel, Christoph; Elshazly, Tarek M.; Alhotan, Abdulaziz (2024-10-18)<strong>Objective:</strong> The objective of this study was to evaluate the effect of different surface treatment methods on the shear bond strength (SBS) of metal brackets bonded to two types of CAD/CAM composite restorations: ... -
Single-neuron representations of odours in the human brain
Kehl, Marcel S.; Mackay, Sina; Ohla, Kathrin; Schneider, Matthias; Borger, Valeri; Surges, Rainer; Spehr, Marc; Mormann, Florian (2024-10-09)Olfaction is a fundamental sensory modality that guides animal and human behaviour. However, the underlying neural processes of human olfaction are still poorly understood at the fundamental—that is, the single-neuron—level. ... -
Microbial Spectrum, Intraoperative Findings, and Postoperative Outcomes in Native Knee Joint Infections: A Retrospective Analysis
Roos, Jonas; Mangels, Britta; Jaenisch, Max; Wimmer, Matthias Dominik; Randau, Thomas Martin; Prangenberg, Christian; Welle, Kristian; Gathen, Martin (2024-12-16)<strong>Background:</strong> Native knee joint infections, while uncommon, present a serious condition predominantly instigated by bacteria such as <em>Staphylococcus aureus</em>. Without timely intervention, they can ... -
From Language Models to Medical Diagnoses: Assessing the Potential of GPT-4 and GPT-3.5-Turbo in Digital Health
Roos, Jonas; Wilhelm, Theresa Isabelle; Martin, Ron; Kaczmarczyk, Robert (2024-12-02)Background: Large language models (LLMs) like GPT-3.5-Turbo and GPT-4 show potential to transform medical diagnostics through their linguistic and analytical capabilities. This study evaluates their diagnostic proficiency ... -
Characterization of the disorganization of the inner retinal layers in diabetics using increased axial resolution optical coherence tomography
Wall, Katharina; Arend, Lilith P.; Emde, Leon von der; Saßmannshausen, Marlene; Holz, Frank G.; Ach, Thomas (2025-01-13)<strong>Purpose:</strong> To compare a novel high-resolution optical coherence tomography (OCT) with improved axial resolution (High-Res OCT) with conventional spectral-domain OCT (SD-OCT) with regard to their capacity to ... -
Mind wandering, poor sleep, and negative affect: a threefold vicious cycle?
Fell, Juergen (2024-09-05)Mind wandering (MW) is intricately linked to sleep and affect, bearing clinical relevance for various psychiatric conditions, notably attention deficit/hyperactivity disorder, depression, and anxiety disorders. Most reviews ... -
Brain and Ventricle Volume Alterations in Idiopathic Normal Pressure Hydrocephalus Determined by Artificial Intelligence-Based MRI Volumetry
Bendella, Zeynep; Purrer, Veronika; Haase, Robert; Zülow, Stefan; Kindler, Christine; Borger, Valerie; Banat, Mohammed; Dorn, Franziska; Wüllner, Ullrich; Radbruch, Alexander; Schmeel, Frederic Carsten (2024-07-03)The aim of this study was to employ artificial intelligence (AI)-based magnetic resonance imaging (MRI) brain volumetry to potentially distinguish between idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease ... -
Evaluating Bard Gemini Pro and GPT-4 Vision Against Student Performance in Medical Visual Question Answering: Comparative Case Study
Roos, Jonas; Martin, Ron; Kaczmarczyk, Robert (2024-12-17)<strong>Background:</strong> The rapid development of large language models (LLMs) such as OpenAI's ChatGPT has significantly impacted medical research and education. These models have shown potential in fields ranging ... -
Efficacy of Virtual Preparation Simulators Compared to Traditional Preparations on Phantom Heads
Stoilov, Lea; Stephan, Fabian; Stark, Helmut; Enkling, Norbert; Kraus, Dominik; Stoilov, Milan (2024-08-14)Background: Virtual simulators are increasingly being introduced in dental education. This study investigates whether virtual simulators offer comparable or superior educational efficacy when compared to traditional phantom ... -
Associations Between Clinical Factors and Postoperative Thrombosis in Pediatric Cardiac Surgery Patients: A Single-Center Retrospective Study
Chlench, Sven; Freudenthal, Noa J. (2024-10-21)<strong>IMPORTANCE:</strong> Postoperative thrombosis is a significant complication in pediatric cardiac surgery patients, contributing to morbidity and mortality. Identifying clinical factors associated with thrombosis ... -
Therapeutic alliance in individual adult psychotherapy: A systematic review of conceptualizations and measures for face-to-face- and online-psychotherapy
Saxler, Eva; Schindler, Theresa; Philipsen, Alexandra; Schulze, Marcel; Lux, Silke (2024-06-27)<strong>Background:</strong> The therapeutic alliance (TA) is a robust and pantheoretical predictor of treatment outcome in Face-to-Face- (F2F-) and Online-psychotherapy (Online-PT). Many authors have proposed several ... -
Force system of 3D-printed orthodontic aligners made of shape memory polymers: An in vitro study
Sharif, Madina; Bourauel, Christoph; Ghoneima, Ahmed; Schwarze, Jörg; Alhotan, Abdulaziz; Elshazly, Tarek M. (2024-06-10)This study aimed to report forces and moments delivered by 3D-printed aligners. Tera Harz TC-85 resin and Zendura FLX (ZF) thermoformed sheets (0.76 mm) were used. Rectangular strip specimens (50 × 10 × 0.6 mm) were produced ... -
Effect of the Height of a 3D-Printed Model on the Force Transmission and Thickness of Thermoformed Orthodontic Aligners
Ghoraba, Omar; Bourauel, Christoph; Aldesoki, Mostafa; Singer, Lamia; Ismail, Ahmed M.; Elattar, Hanaa; Alhotan, Abdulaziz; Elshazly, Tarek M. (2024-06-20)This research aims to investigate the influence of model height employed in the deep drawing of orthodontic aligner sheets on force transmission and aligner thickness. Forty aligner sheets (Zendura FLX) were thermoformed ... -
Retro Mode Imaging for Detection and Quantification of Sub-RPE Drusen and Subretinal Drusenoid Deposits in Age-Related Macular Degeneration
Saßmannshausen, Marlene; Sautbaeva, Leyla; Emde, Leon Alexander von der; Vaisband, Marc; Sloan, Kenneth R.; Hasenauer, Jan; Holz, Frank G.; Ach, Thomas (2024-07-15)<strong>Background:</strong> Drusen and drusenoid deposits are a hallmark of age-related macular degeneration (AMD). Nowadays, a multimodal retinal imaging approach enables the detection of these deposits. However, ... -
Diagnoses and Treatment Recommendations—Interrater Reliability of Uroflowmetry in People with Multiple Sclerosis
Jaekel, Anke Kirsten; Rieger, Julia; Butscher, Anna-Lena; Möhr, Sandra; Schindler, Oliver; Queissert, Fabian; Hofmann, Aybike; Schmidt, Paul; Kirschner-Hermanns, Ruth; Knüpfer, Stephanie C. (2024-07-18)Background: Uroflowmetry (UF) is an established procedure in urology and is recommended before further investigations of neurogenic lower urinary tract dysfunction (NLUTD). Some authors even consider using UF instead of ...