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Additive prognostic impact of the cerebrospinal fluid arginine/ornithine ratio to established clinical scores in aneurysmal subarachnoid hemorrhage
(2023-04-14)Cerebrospinal fluid (CSF) metabolites are increasingly recognized as prognostic factors in aneurysmal subarachnoid hemorrhage (SAH). The CSF arginine/ ornithine ratio (Arg/Orn) was shown to predict cerebral vasospasms ... -
Alpha modulation via transcranial alternating current stimulation in adults with attention-deficit hyperactivity disorder
(2024-01-12)<strong>Background:</strong> One potential therapy treating attention-deficit/hyperactivity disorder (ADHD) is to modulate dysfunctional brain activations using brain stimulation techniques. While the number of studies ... -
Altered interaction of physiological activity and behavior affects risky decision-making in ADHD
(2023-04-20)<b>Background:</b> Adult attention-deficit/hyperactivity disorder (ADHD) is often associated with risky decision-making behavior. However, current research studies are often limited by the ability to adequately reflect ... -
Assessing the quality of life of patients with metastatic castration-resistant prostate cancer with bone metastases receiving [223Ra]RaCl2 therapy
(2020-08-19)[<sup>223</sup>Ra]RaCl<sub>2</sub> dichloride treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) is associated with improved overall survival (OS) and a delay in the time to the first ... -
Attention Deficit Hyperactivity Disorder: A Risk Factor for Premature Discontinuation of Inpatient Opioid Withdrawal Treatment
(2024-06-03)<strong>Background:</strong> Substance use disorders present a tremendous challenge within contemporary healthcare systems. Specifically, in the domain of opioid use disorders (OUDs), several foundational elements are ... -
Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres
(2012-05-01)DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed ... -
Comparison between regular additional endobiliary radiofrequency ablation and photodynamic therapy in patients with advanced extrahepatic cholangiocarcinoma under systemic chemotherapy
(2023-08-29)<strong>Background and aims: </strong>Extrahepatic cholangiocarcinoma (eCCA) remains a malignancy with a dismal prognosis. The first-line standard of care includes systemic chemotherapy (SC) and biliary drainage through ... -
Congenital Gerbode Defect: A Left Ventricular to Right Atrial Shunt: State-of-the-Art Review of Its General Data, Diagnostic Modalities, and Treatment Strategies
(2024-05-28)The congenital Gerbode defect is defined as an abnormal communication between the left ventricle and the right atrium. This review aimed to summarize existing evidence, shed light on the clinical implications, and identify ... -
Cost-effectiveness and Quality of Specialized and Routine Care in a German Cohort of Patients with Chronic Pruritus
(2023-04-21)Chronic pruritus is a prevalent interdisciplinary symptom with a strong influence on health-related quality of life. Patients need extensive diagnostics and long-term treatment. This retrospective and prospective cohort ... -
Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy
(2022-09-01)Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen ... -
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes
(2020-10-12)<em>DHX36</em> is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was ... -
Deficient immune response following SARS-CoV-2 vaccincation in patients with hepatobiliary carcinoma: A forgotten, vulnerable group of patients
(2023-05-10)<strong>Introduction:</strong> Data on immune response rates following vaccination for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in patients with hepatobiliary carcinoma (HBC) are rare. However, impaired ... -
Detecting G4 unwinding
(2022-04-18)DNA can, in addition to the B-DNA conformation, fold into a variety of additional conformations. Among them are G-quadruplex structures that have gained a lot of attention in recent years. G-quadruplex structures (G4s) are ... -
Differential modulation of resting-state functional connectivity between amygdala and precuneus after acute physical exertion of varying intensity: Indications for a role in affective regulation
(2024-04-04)<strong>Introduction:</strong> Physical activity influences psychological well-being. This study aimed to determine the impact of exercise intensity on psychological well-being and alterations in emotion-related brain ... -
Effects of a video game intervention on symptoms, training motivation, and visuo-spatial memory in depression
(2023-08-24)<strong>Background:</strong> People with Major Depressive Disorder (MDD) often experience reduced affect, mood, and cognitive impairments such as memory problems. Although there are various treatments for MDD, many of them ... -
Effects of Different Titanium Surface Treatments on Adhesion, Proliferation and Differentiation of Bone Cells: An In Vitro Study
(2022-09-05)The objective of this study was to evaluate the impacts of different sandblasting procedures in acid etching of Ti6Al4V surfaces on osteoblast cell behavior, regarding various physicochemical and topographical parameters. ... -
Evolving the Era of 5D Ultrasound?: A Systematic Literature Review on the Applications for Artificial Intelligence Ultrasound Imaging in Obstetrics and Gynecology
(2023-10-29)Artificial intelligence (AI) has gained prominence in medical imaging, particularly in obstetrics and gynecology (OB/GYN), where ultrasound (US) is the preferred method. It is considered cost effective and easily accessible ... -
Experimental Induction of Micro- and Macrosomatognosia: A Virtual Hand Illusion Study
(2021-04-29)Although body size misperceptions are known to occur under various neurological and psychiatric conditions, their neurocognitive underpinnings are not yet resolved. Accordingly, it would be beneficial to have an experimental ... -
Experimental Induction of Micro- and Macrosomatognosia: A Virtual Hand Illusion Study
(2021-04-29)Although body size misperceptions are known to occur under various neurological and psychiatric conditions, their neurocognitive underpinnings are not yet resolved. Accordingly, it would be beneficial to have an experimental ... -
Fractional amplitude of low-frequency fluctuations associated with μ-opioid and dopamine receptor distributions in the central nervous system after high-intensity exercise bouts
(2024-02-22)<strong>Introduction:</strong> Dopaminergic, opiod and endocannabinoid neurotransmission are thought to play an important role in the neurobiology of acute exercise and, in particular, in mediating positive affective ...
