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Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins

dc.contributor.advisorGütschow, Michael
dc.contributor.authorBreuer, Christian
dc.date.accessioned2020-04-27T14:13:30Z
dc.date.available2021-02-15T23:02:25Z
dc.date.issued07.02.2020
dc.identifier.urihttps://hdl.handle.net/20.500.11811/8266
dc.description.abstractThe present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.en
dc.language.isoeng
dc.rightsIn Copyright
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subject.ddc500 Naturwissenschaften
dc.subject.ddc540 Chemie
dc.subject.ddc610 Medizin, Gesundheit
dc.titleDesign and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
dc.typeDissertation oder Habilitation
dc.publisher.nameUniversitäts- und Landesbibliothek Bonn
dc.publisher.locationBonn
dc.rights.accessRightsopenAccess
dc.identifier.urnhttps://nbn-resolving.org/urn:nbn:de:hbz:5-57228
ulbbn.pubtypeErstveröffentlichung
ulbbnediss.affiliation.nameRheinische Friedrich-Wilhelms-Universität Bonn
ulbbnediss.affiliation.locationBonn
ulbbnediss.thesis.levelDissertation
ulbbnediss.dissID5722
ulbbnediss.date.accepted10.01.2020
ulbbnediss.instituteMathematisch-Naturwissenschaftliche Fakultät : Fachgruppe Pharmazie / Pharmazeutisches Institut
ulbbnediss.fakultaetMathematisch-Naturwissenschaftliche Fakultät
dc.contributor.coRefereeBendas, Gerd


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