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Intervertebral Disc and Adipokine Leptin—Loves Me, Loves Me Not

dc.contributor.authorCuric, Goran
dc.date.accessioned2021-11-30T12:47:14Z
dc.date.available2021-11-30T12:47:14Z
dc.date.issued31.12.2020
dc.identifier.urihttps://hdl.handle.net/20.500.11811/9434
dc.description.abstractLeptin—the most famous adipose tissue-secreted hormone—in the human body is mostly observed in a negative connotation, as the hormone level increases with the accumulation of body fat. Nowadays, fatness is becoming another normal body shape. Fatness is burdened with numerous illnesses-including low back pain and degenerative disease of lumbar intervertebral disc (IVD). IVD degeneration and IVD inflammation are two indiscerptible phenomena. Irrespective of the underlying pathophysiological background (trauma, obesity, nutrient deficiency), the inflammation is crucial in triggering IVD degeneration. Leptin is usually depicted as a proinflammatory adipokine. Many studies aimed at explaining the role of leptin in IVD degeneration, though mostly in in vitro and on animal models, confirmed leptin's "bad reputation". However, several studies found that leptin might have protective role in IVD metabolism. This review examines the current literature on the metabolic role of different depots of adipose tissue, with focus on leptin, in pathogenesis of IVD degeneration.en
dc.format.extent23
dc.language.isoeng
dc.rightsNamensnennung 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectleptin
dc.subjectobesity
dc.subjectintervertebral disc
dc.subjectlow back pain
dc.subjectinflammation
dc.subject.ddc610 Medizin, Gesundheit
dc.titleIntervertebral Disc and Adipokine Leptin—Loves Me, Loves Me Not
dc.typeWissenschaftlicher Artikel
dc.publisher.nameMDPI
dc.publisher.locationBasel
dc.rights.accessRightsopenAccess
dcterms.bibliographicCitation.volume2021
dcterms.bibliographicCitation.issue22(1), 375
dcterms.bibliographicCitation.pagestart1
dcterms.bibliographicCitation.pageend23
dc.relation.doihttps://doi.org/10.3390/ijms22010375
dcterms.bibliographicCitation.journaltitleInternational Journal of Molecular Sciences
ulbbn.pubtypeZweitveröffentlichung
dc.versionpublishedVersion
ulbbn.sponsorship.oaUnifundOA-Förderung Universität Bonn


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