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The role of the cannabinoid receptor 2 in alcohol-induced neuroinflammation and alcohol addiction
(2015-02-11)Chronic alcohol abuse leads to severe brain damage, which has been associated with alcohol-induced neuroinflammation. Recently, the cannabinoid receptor 2 (CB<sub>2</sub>), which is predominantly expressed on immune cells, ... -
Role of the cannabinoid receptor 2 in the development of surgical neuropathic pain
(2018-12-12)When normal nociceptive pain becomes chronic, it loses its protective function and causes a general pain hypersensitivity. Neuropathic pain is one type of chronic pain, which is caused by various diseases or physical injury ... -
The role of the cannabinoid receptor 2 in the modulation of neuropathic pain
(2013-11-19)Neuropathic pain is a debilitating, chronic pain condition associated with inflammation or injury of peripheral and central nerves (Milligan and Watkins, 2009). The existing pharmacotherapies either lead to an inadequate ... -
The role of the CC chemokine CCL17 in a mouse model of Alzheimer’s disease
(2013-07-25)In Alzheimer's disease (AD), inflammatory processes are critically involved by cells releasing neurotoxic or neurotrophic factors influencing survival of neurons and synapses, and thereby cognitive behavior. Several ... -
Role of the CCL17/CCL22-CCR4-axis in the barrier organs skin and gut
(2024-07-18)(noch nicht zugänglich / not yet accessible) -
The role of the chemokine receptor CXCR3 in mouse models for IL-12-driven CNS-inflammation and Morbus Alzheimer-like neurodegeneration
(2013-01-31)The chemokine receptor CXCR3 and its corresponding ligands CXCL9, CXCL10 and CXCL11 are well known to be involved in the trafficking and migration of activated CD4<sup>+</sup> Th1 T cells, CD8<sup>+</sup> T cells and NK ... -
Role of the chemokines CCL17 and CCL22 in bacterial infection and IL-33-induced immune responses
(2023-11-24)The chemokines CCL17 and CCL22 are primarily expressed by dendritic cells (DC) and macrophages. Both chemokines share the receptor CCR4, which is expressed on DC and macrophages as well as on a variety of different T cell ... -
Role of the chemokines CCL17 and CCL22 in the immune defence against Salmonella infection
(2020-03-17)The chemokines CCL17 and CCL22 are both ligands of the chemokine receptor CCR4, which is expressed on dendritic cells (DC) and a variety of different effector T cells including regulatory T cells (Treg). Both chemokines ... -
The role of the endocannabinoid receptor CB2 in a mouse model of Alzheimer's disease
(2018-09-26)Over the past years, an important role of the cannabinoid receptor 2 (CB2) has been implicated in several neurological and immunological conditions, such as experimental autoimmune encephalitis, stroke, memory, neuropathic ... -
The role of the endocannabinoid system in brain and systemic ageing
(2024-01-15)Previous research from our laboratory has demonstrated that genetic manipulations leading to reduced CB1 receptor signaling in mice accelerated the ageing process. Specifically, the constitutive deletion of the CB1 receptor ... -
The role of the endocannabinoid system in stress-related disorders and neuroimmune communication
(2020-05-04)In the last decades, increasing evidence suggests that inflammatory processes play an important role in the development of psychiatric disorders, such as anxiety and depression. Psychosocial stress – one of the main ... -
The role of the Hippo pathway in etiology and progression of pancreato-biliary tumors and clear cell renal cell carcinoma
(2016-01-21)In the quest for the discovery of novel targets for cancer therapy, aberrantly reactivated embryonic signaling pathways have proven to be a rich mine and recent years have seen the introduction of the hedgehog-inhibitor ... -
The role of the miR-17-92 cluster in macrophage driven innate immunity
(2018-12-11)Research into miRNA, discovered in 1993, has exploded and revolutionized our understanding of molecular regulation in biological systems. MicroRNAs are now a well established as a regu- latory mechanism of many pathways ... -
Role of the proton channel HVCN1 in the regulation of neutrophil activation
(2023-06-22)Excessive neutrophil activation is a feature of many inflammatory diseases. Neutrophils from affected patients are prone to release reactive oxygen species (ROS) and toxic granule proteins or to undergo NETosis, a special ... -
Role of the Receptor for Advanced Glycation End-products (RAGE) in the Immune Sensing of Nucleic Acids
(2016-09-06)Nucleic acid recognition is an important mechanism that enables the innate immune system to detect both microbial infection and tissue damage. To minimize the recognition of self-derived nucleic acids, all nucleic acid ... -
The role of the salvage pathway of phytol, geranylgeraniol, and farnesol phosphorylation in Arabidopsis thaliana
(2021-03-09)The isoprenoid alcohol phytol can be phosphorylated in Arabidopsis to phytyl-phosphate (phytyl-P) by the phytol kinase (VTE5) and further to phytyl-diphosphate (phytyl-PP) by the phytyl phosphate kinase (VTE6). Phytyl-PP ... -
The role of the stemness factor Nanog in cell cycle regulation
(2011-01-12)Pluripotency of embryonic stem (ES) cells is maintained through various extrinsic and intrinsic influences. In the center of intrinsic stemness signaling, a triad of transcription factors, namely Nanog, Oct3/4 and Sox2, ... -
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ... -
The role of the zinc finger transcription factor Gli3 in murine hindbrain development
(2019-07-15)The zinc finger transcription factor GLI3 is a downstream component of the Sonic Hedgehog signaling pathway and functions mostly as a transcriptional repressor. GLI3 is required for the proper development of dorsal forebrain, ... -
Role of TLR2 in immune sensing of gut microbiota in RNA virus induced glomerulonephritis
(2024-05-22)Chronically infected patients with human immune deficiency virus (HIV) are at high risk of developing autoimmune diseases. Despite successful anti-retroviral therapy, autoimmune diseases and renal diseases affect 10–15 % ...
