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Synthese und Reaktionen von phosphorfunktionalisierten 1,3-Dithiol-2-thionen
(2021-01-05)
Die Dissertation "Synthese und Reaktionen von phosphorfunktionalisierten 1,3-Dithiol-2-thionen" beschreibt die Darstellung von tricyclischen 1,4-Dihydro-1,4-diphosphininen, die 1,3-Dithiol-2-thion-Einheiten tragen. Zugleich ...
Network effects of eslicarbazepine in the hippocampus
(2020-05-18)
Nearly 50 million people worldwide suffer from epilepsy, with 1/3 of the patients remaining without seizure control. This high number emphasizes the importance to develop new anti-epileptic drugs (AEDs) and to understand ...
Soviet and contemporary Russian foreign policy comparative perspective: Analyzed through three case-studies: Egypt, Syria, and Iran
(2022-02-21)
What are the main similarities and distinctions in Russian foreign policy conduct before and after the dissolution of the Soviet Union? This question will be addressed through comparative analysis between the Soviet and ...
Modularity of strings on F-theory backgrounds
(2022-04-04)
This thesis regards topological string theory on elliptically and genus one fibered Calabi-Yau compactifications to study counting indexes over states in a dual six-, five-, and four-dimensional theory realized by F-theory.
Biochemical characterization of the human Cyclin-dependent kinases Cdk7 and Cdk10
(2021-08-13)
Protein kinases comprise a large superfamily of enzymes regulating a plethora of cellular processes. Dysregulation of protein kinases, such as loss of activity, hyperactivity or mislocalisation, is often accompanied with ...
Development of Computational Methods for Rationalizing Chemical Lead Optimization and Compound Design
(2021-09-22)
Chemical lead optimization (LO) plays an important role in pharmaceutical drug discovery. It represents a highly complex multi-objective process, in which the ultimate goal is to identify a suitable candidate molecule that ...
Role of innate lymphoid cells in type 1-dominated experimental Plasmodium berghei ANKA and type 2-dominated Litomosoides sigmodontis infection
(2021-10-27)
Malaria and filariasis remain among the biggest health problems in the tropics and subtropics, especially in Africa, and in the case of malaria among the ten most frequent causes of death. The parasites that cause malaria ......
The Hubbard Model on the Honeycomb Lattice with Hybrid Monte Carlo
(2021-11-09)
We take advantage of recent improvements in the grand canonical Hybrid Monte Carlo (HMC) algorithm, to perform a precision study of the single-particle gap in the hexagonal Hubbard model, with on-site electron-electron ...
Bedeutung des Inflammasoms für das kardiale Remodelling nach Ischämie/Reperfusion am murinen Modell
(2022-04-04)
Zahlreiche experimentelle Strategien zur Therapie des Myokardinfarkts zielen auf eine Reduktion des sogenannten Reperfusionsschadens ab. Ein großer Anteil des postischämischen myokardialen Funktionsverlustes wird diesem ...
Supersymmetric methods in random matrix theory
(2021-12-02)
Randomness and chaos are key ingredients in the description of nature and are therefore central elements in mathematics and physics. A conducting metal becomes an insulator if there are enough random defects in its structure. ...