E-Dissertationen: Auflistung E-Dissertationen nach Titel
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Development of a Laboratory Readout System for DEPFET Pixel Detector Modules and Investigation of Radiation Backgrounds at the SuperKEKB Accelerator
Ahlburg, Patrick (2023-01-23)With the upgrade from the e^+ e^- -collider KEKB to SuperKEKB, a 40-fold increase in instantaneous luminosity is targeted posing new challenges for the Belle II detector. Particularly the innermost detector layers, consisting ... -
Development of a new reconstruction and classification method for Tau leptons and its application in the ATLAS detector at the LHC
Limbach, Christian (2015-05-13)This thesis presents a new method for the reconstruction and classification of hadronically decaying tau leptons in the ATLAS detecor at the LHC. It also presents a possible application of the new methods.<br /> The new ... -
Development of a satellite-based dynamic regional vegetation model for the Drâa catchment
Fritzsche, Pierre (2011-02-07)Analysing and modelling land cover dynamic of the vegetation under a changing hydrological cycle inside the semi-arid area resulting from the global climate change are a difficult task. It is important to be able to ... -
Development of a serial powering scheme and a versatile characterization system for the ATLAS pixel detector upgrade
Filimonov, Viacheslav (2017-08-22)In order to increase the probability of new discoveries the LHC will be upgraded to the HL-LHC. The upgrade of the ATLAS detector is an essential part of this program. The entire ATLAS tracking system will be replaced by ... -
Development of anFPGA-based Data Reduction System for the Belle II DEPFET Pixel Detector
Schnell, Michael (2015-07-14)The innermost two layers of the Belle II detector at the KEKB collider in Tsukuba, Japan will be covered by highly granular DEPFET pixel sensors. The large number of pixels lead to a maximum data rate of 256 Gbps, which ... -
Development of capillary electrophoresis-based assays for nucleoside and nucleotide metabolizing enzymes
Iqbal, Jamshed (2005)The aim of the present work was to develop and optimise capillary electrophoresis-based methods for the assaying of nucleoside and nucleotide metabolizing enzymes.<br /> More specifically the aim included: <ul><li>Developing ... -
Development of Cell-Based Assays for Adenine Receptors and Selected Purine Receptor Subtypes: Receptor Characterization and Search for Novel Ligands
Abdelrahman, Aliaa Mahmoud Mohamed Eltayb (2011-01-04)The thesis deals with the development of different cell-based assay techniques in order to characterize the receptors under investigation at the protein level, mapping of the distribution of the receptors of interest in ... -
The Development of Chiral Titanocenes as Photoredox Catalysts
Slak, Daniel (2023-01-24)This dissertation describes the advances in photochemically activated (chiral) titanocenes as both electron transfer and photoredox catalysts in epoxide opening reactions. Based on the discovery of the photoredox-active ... -
Development of Computational Methods for Rationalizing Chemical Lead Optimization and Compound Design
Yonchev, Dimitar (2021-09-22)Chemical lead optimization (LO) plays an important role in pharmaceutical drug discovery. It represents a highly complex multi-objective process, in which the ultimate goal is to identify a suitable candidate molecule that ... -
Development of depleted monolithic active pixel sensors for high rate and high radiation experiments at HL-LHC
Hirono, Toko (2019-07-10)Depleted monolithic active pixel sensors (DMAPS) are developed to demonstrate their suitability for high energy particle physics experiments in high radiation and high hit-rate environments. In this thesis, characterization ... -
Development of Efficient and Accurate Approximations to Single Reference Correlation Methods using Pair Natural Orbitals
Hansen, Andreas (2012-09-14)Computational chemistry greatly enhances the scientific analysis of experiments and can predict quantities that are experimentally not accessible. However, there is still no approximate method available that is both efficient ... -
Development of efficient tools for monitoring and improvement of biogas production
Refai, Sarah (2017-03-29)Biomass from energy crops and organic waste is one of the most important renewable energy sources and can be used for the production of biogas. Biogas formation is based on the fermentation of organic matter and is performed ... -
Development of Enzyme Replacement and Pharmacological Chaperone Approaches for Therapy of Metachromatic Leukodystrophy
Schuster, Tilman (2015-01-06)Metachromatic leukodystrophy (MLD) is a monogenic, autosomally recessively inherited lysosomal storage disease. Certain mutations of the arylsulfatase A (ASA) gene cause misfolding or absence of ASA. Physiologically ASA ... -
Development of high speed integrated circuit for very high resolution timing measurements
Mester, Christian (2009-12-07)A multi-channel high-precision low-power time-to-digital converter application specific integrated circuit for high energy physics applications has been designed and implemented in a 130 nm CMOS process. To reach a target ... -
Development of Methods for Solid Phase Synthesis of Polyamine Conjugates and Initial Biological Evaluation of Their Potential to Enhance Cellular Uptake
Hahn, Frank (2008)Cationic peptides have shown their potency to efficiently enhance cellular uptake of covalently coupled molecules. In order to avoid their rapid degradation by peptidases, diverse classes of peptide mimics like peptoids, ... -
Development of Molecular Chimeras Targeting the NLRP3 Inflammasome and HDAC6
Keuler, Tim (2024-03-28)(noch nicht zugänglich / not yet accessible) -
Development of New Breast Cancer Resistance Protein Inhibitors
Juvale, Kapil (2013-07-09)Chemotherapy is a major form of treatment for cancers. Unfortunately, the majority of cancers are either resistant to chemotherapy or acquire resistance (MDR) during treatment. The most common mechanism by which human ... -
Development of New Multistate Multireference Perturbation Theory Methods and Their Application
Lang, Lucas (2020-07-14)The present work is concerned with the development and application of two new multistate multireference perturbation theory methods, which can simultaneously provide several states that are allowed to mix under the influence ... -
Development of oligomer-specific antibodies against tau protein and testing of therapeutic potential in a cell model of tau pathology
Chandupatla, Ram Reddy (2020-04-15)Tau, a microtubule associated protein, forms abnormal aggregates in many neurodegenerative diseases such as Alzheimer disease (AD). There is an urgent need for disease-modifying therapies of AD and related tauopathies. ... -
Development of pharmacological modulators for the orphan G protein-coupled receptor GPR17 and their application for the investigation of molecular signal transduction pathways
Spinrath, Andreas (2011-11-29)In order to discover a set of tools suitable to be employed in its in vitro characterization, the recently deorphanized G protein coupled receptor GPR17 was investigated by using different classical second messenger assays ...