E-Dissertationen: Auflistung E-Dissertationen nach Titel
Anzeige der Dokumente 3125-3144 von 4071
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The role of GPR111 in adipose tissue
(2021-05-21)Due to obesity pandemic and limited therapeutic approaches, novel targets of pharmaceutical treatments are urgently needed. AT as a very important metabolic organ is an attractive target for combating obesity and obesity ... -
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ... -
The role of guanine nucleotide exchange factors in the regulation of immune cell signaling
(2009-07-08)The ARF GEF cytohesin-1 was originally identified as β2-integrin binding protein, and was shown to play an important role in the control of integrin-dependent immune cell migration and adhesion via activating the small ... -
Role of IgG4-mediated Suppression of Immune Effector Mechanisms in Human Filariasis
(2017-03-15)Lymphatic filariasis (LF) is a major public health concern in tropical and subtropical countries. The infection affects more than 120 million people and has significant social and economic consequences on affected individuals ... -
Role of innate lymphoid cells in type 1-dominated experimental Plasmodium berghei ANKA and type 2-dominated Litomosoides sigmodontis infection
(2021-10-27)Malaria and filariasis remain among the biggest health problems in the tropics and subtropics, especially in Africa, and in the case of malaria among the ten most frequent causes of death. The parasites that cause malaria ... -
The Role of Inosine in Adipose Tissue Metabolism
(2022-05-02)During the last decades, obesity has become a pandemic disease, associated with severe comorbidities, and a major problem for health care systems. Obesity results from energy imbalance, when energy intake exceeds energy ... -
Role of interleukin-6 during infection with the filarial nematode Litomosoides sigmodontis
(2013-12-04)Lymphatic filariasis is a neglected tropical disease that is caused by parasitic helminths and affects 120 million people worldwide, while 1.3 billion people live in endemic areas. Three species of tissue dwelling nematodes ... -
The role of linear energy transfer in modulating radiationinduced NF-κB activation and its down-stream target genes
(2014-07-23)To enable long-term human spaceflight, the cellular radiation response to heavy ions with a high linear energy transfer (LET) needs to be better understood for developing appropriate countermeasures to mitigate acute effects ... -
Role of long-range CA3 connectivity in linking spatial and aversive information
(2022-04-12)The CA3 region of the hippocampus is an auto-associative network that is thought to enable rapid associations between spatial locations and non-spatial information. As such, it is important for retention and retrieval of ... -
The role of mass movements for slope evolution: conceptual approaches and model applications in the Bonn area
(2001)Understanding slope processes and slope systems in different timescales is focused by a range of approaches from different disciplines. This work is based on a multi-disciplinary research approach within the project SFB350 ... -
Role of membrane lipids in regulation of Alzheimer’s disease associated proteins and vice-a-versa
(2008)Alzheimer’s disease (AD) is associated with extracellular deposits of the amyloid β- peptide (Aβ) and intraneuronal aggregates of hyperphosphorylated tau protein in the brain. Aβ is generated by sequential proteolytic ... -
The Role of microRNAs in the Regulation of Human UDP-glucuronosyltransferases (UGTs)
(2021-06-14)The liver is involved in endo- and xenobiotic metabolism due to the expression of drug-metabolizing UDP-glucuronosyltransferases (UGTs). By UGT-mediated elimination of hazardous compounds and other reactive metabolites, ... -
The role of MyD88-dependent signaling pathways in skin mast cells in UVB-induced skin diseases
(2022-03-04)Excessive UV irradiation is a major risk factor for health. While chronic long-term UV exposure induces skin aging and suppression of the immune system, acute UV exposure leads to skin inflammation, also known as sunburn. ... -
The Role of NMDA Receptor Co-Agonists in Dendritic Integration
(2021-03-26)The integration of synaptic inputs is the fundamental function of neurons. This integration does not only take place at the soma, but also dendrites can actively shape the input-output computations of a neuronal network. ... -
Role of Pathogenic Mediators in murine Arthritis and Levels of Serum Soluble CD21 and CD23 in autoimmune patients
(2009-03-23)Importance of the nervous system in immune regulation is clearly suggested by innervations of lymphoid tissues by sympathetic nerve fibers. We determined the role of sympathetic, parasympathetic and peripheral nervous ... -
The Role of Phytol Degradation in Chlorophyll and Tocopherol (Vitamin E) Metabolism
(2021-10-14)The phytol degradation in the model plant Arabidopsis thaliana was studied. Phytol is the hydrophobic side of chlorophyll and is considered to be most abundant isoprenoid molecule in the biosphere. But the degradation of ... -
The role of PPARγ in myeloid cells in experimental autoimmune encephalomyelitis
(2013-05-06)Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the central nervous system (CNS) affecting more than 1 million people worldwide. It mainly affects young adults and has a great impact on ... -
Role of presenilins in autophagy and growth factor signaling
(2021-02-08)Alzheimer's disease is the most common neurodegenerative disease and affects millions of people worldwide. To date, no efficient therapies are known for a cure. As people suffering from diabetes mellitus type 2 have an ... -
The role of soil heterogeneity on field scale evapotranspiration: 3D integrative modelling and upscaling of root water uptake
(2015-09-24)Background and Motivation: Hydrological models mainly rely on empirical functions to describe root water uptake. However, in case of water limitation due to either scarce or heterogeneously distributed soil water, ... -
The role of soluble guanylate cyclase in metabolism
(2018-10-31)Obesity is a worldwide health problem characterized by a chronic positive energy balance. The excess energy is stored primarily as lipids (TGs) in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) utilizes ...
