E-Dissertationen: Browsing E-Dissertationen by Author "Sahl, Hans-Georg"
Now showing items 1-20 of 38
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Aggregatbildung des Lantibiotikums Nisin mit Baktoprenolkomponenten der bakteriellen Zellwandbiosynthese
Scherer, Katharina Maria (2015-07-16)Wie andere antimikrobielle Peptide besitzt das Lantibiotikum Nisin die Fähigkeit, eine Membran zu perforieren, wenn es in mikromolaren Konzentrationen eingesetzt wird. In Anwesenheit des bakteriellen Zellwandvorläufermoleküls ... -
Antibacterial treatment of Staphylococcus aureus: Response and resistance to the lantibiotic mersacidin and evaluation of endolysins as a biofilm treatment strategy
Saß, Peter (2009-08-17)Staphylococcus aureus, both a commensal organism and an important human pathogen, has been the objective of basic and clinical research for decades. S. aureus is the leading cause for a broad range of diseases, such as ... -
Antibiotic mechanisms of invertebrate and mammalian defensins
Wilmes, Miriam (2013-02-19)Multicellular organisms defend themselves against infectious microorganisms by producing a wide array of antimicrobial peptides referred to as host defence peptides (HDPs). These evolutionary ancient peptides are important ... -
Antibiotika-Multiresistenz bei Pseudomonas aeruginosa
Henrichfreise, Beate (2006)In der vorliegenden Arbeit wurden auf molekularer Ebene die Resistenzmechanismen multiresistenter Stämme von P. aeruginosa, einem der häufigsten Erreger nosokomialer Infektionen, in deutschen Krankenhäusern untersucht. ... -
Assessment of virulence factors of a reservoir-borne SARS-related coronavirus by reverse genetics
Muth, Doreen (2013-01-04)The pandemic of the „Severe acute respiratory syndrome“ (SARS) at the end of 2002 caused more than 8000 infections and led to more than 800 deaths. The disease was soon associated with a new zoonotic coronavirus, the ... -
The Binding Behavior of Daptomycin on the Bacterial Membranes
Liu, Xinliang (2018-07-24)Daptomycin (DAP) is a cyclic anionic lipopeptide antibiotic that kills gram-positive bacteria via cell membrane distortion. It is currently approved for treatment of complicated infections caused by gram-positive bacteria, ... -
Biosynthesis of soluble capsule precursors in Staphylococcus aureus
Ulm, Hannah (2016-11-28)Most invasive pathogens produce polysaccharide capsules, which play an essential role in conferring protection against host immune defense. In the case of Staphylococcus aureus, most clinical isolates are encapsulated, ... -
Characterization of Staphylococcus aureus antigen-specific antibodies and application of their epitopes as active vaccine against MRSA
Nicolai, Anne Kristin (2017-09-21)Patients infected with the life-threatening, methicillin-resistant, human pathogen Staphylococcus aureus (MRSA) can be treated only with antibiotics of last resort. The development of a vaccine as an alternative ... -
Chitosan as an antimicrobial compound: Modes of action and resistance mechanisms
Fouad, Dina Raafat Gouda (2008)Chitosan, a polysaccharide biopolymer, combines a group of physicochemical and biological characteristics, which allow for a wide range of applications. In this study, we investigated the in vitro antimicrobial ... -
Distribution and genetic composition of carbapenem-resistance determinants in clinical Acinetobacter isolates – focus on carbapenem-hydrolysing β-lactamases
Zander, Esther (2015-02-11)Acinetobacter baumannii is of global concern in health-care facilities as it can easily thrive in the hospital environment and infections can be difficult to treat. Widespread multi-drug (MDR) resistance and a ... -
Der Einfluss von Ca2+-Ionen auf die Aktivität von Mersacidin und Mersacidin-ähnlichen Lantibiotika
Böttiger, Tim (2009-05-08)Das Typ-B-Lantibiotikum Mersacidin entfaltet seine antibakterielle Aktivität, indem es spezifisch über ein konserviertes Bindemotiv mit der ultimativen Zellwandvorstufe Lipid II interagiert und dadurch den Transglykosyli ... -
Wolbachia, endosymbionts of arthropods and filarial nematodes: Requirement of cell wall biosynthesis for cell division And Replication in a host cell-free culture
Vollmer, Jennifer (2013-03-13)Obligate intracellular endobacteria of the genus Wolbachia are widespread in arthropods and filarial nematodes. In disease-causing filarial nematode species, responsible for over 150 million cases of human filariasis in ... -
Das essentielle YycFGHI-Regulationssystem von Staphylococcus aureus: Charakterisierung von Überexpressions-Mutanten und die Etablierung zweier in vitro-Modellsysteme
Türck, Michael (2009-10-08)Bei dem essentiellen Zwei-Komponenten-Regulationssystem (TCS, two-component regulatory system) YycFG handelt es sich um ein hochkonserviertes System, das aus der Sensor-Histidin-Kinase YycG und ihrem zugehörigen Responseregulator ... -
Etablierung eines Testverfahrens zur Prüfung sporizider Flächendesinfektionsmittel: mit dem Schwerpunkt Clostridium difficile Ribotyp 027
Gemein, Stefanie (2011-11-15)Sporenbildende Bakterien wie Clostridium difficile, sind zur Ausbildung von Dauerformen, so genannten Endosporen, befähigt. Diese Sporen sind besonders umweltresistent und stellen erhöhte Anforderungen an ... -
Etablierung von Zellkultur und Tiermodellen zum Studium neu identifizierter Atemwegspathogene (hMPV, hCoV-NL63 und SARS-CoV)
Ditt, Vanessa Alexandra (2011-03-15)Im Rahmen der vorliegenden Dissertation wurden das humane Metapneumovirus (hMPV) und das respiratorische Synzitial Virus (hRSV) in vitro und in vivo untersucht.
Beide Viren entstammen der Familie der ... -
Evaluation of Wolbachia depletion after antibiotic treatment using real-time PCR in Onchocerciasis and Lymphatic Filariasis, and analysis of genetic associations in Lymphatic Filariasis
Albers, Anna Christina (2011-11-15)Two of the major filarial infections, onchocerciasis and LF, affect > 150 million people. Currently, control programs use yearly mass application of drugs that mainly kill microfilaria (Mf) with the aim to prevent uptake ... -
Expression und Untersuchung von Enzymen der Pederin-Biosynthese aus einem nicht kultivierten Symbionten
Zimmermann, Katrin (2008)Die vorliegende Arbeit beschäftigt sich mit Enzymen des ped-Genclusters aus einem bisher nicht kultivierten Symbionten.
Der ped-Cluster gehört zu Typ-I-Polyketidsynthasen (PKS), in denen die Acyltrans-ferasen (AT) ... -
Expressionssysteme zur Untersuchung der Pederin- und Psymberin-Biosynthese aus nicht kultivierten bakteriellen Symbionten
Niederkrüger, Holger (2011-03-25)Die vorliegende Arbeit beschäftigt sich mit der Expression und Charakterisierung von Enzymen der Pederin- und Psymberin-Biosynthese sowie mit den Fortschritten in der heterologen Expression des Pederin-Genclusters. Pederin ... -
Identification of a putative Litomosoides sigmodontis phosphate permease, Ls-ppe-1, and its role in the interaction between filarial nematodes and their Wolbachia endosymbionts & Establishment of RNA interference in the rodent filaria Litomosoides sigmodontis, a model of human filariasis
Klemm, Claudia Ulrike (2009-12-09)Filariasis is a vector-borne disease that affects 200 million individuals in the tropics, a large number of them seriously, where the disease leads to blindness (onchocerciasis) or elephantiasis (lymphatic filariasis). The ... -
Impairment of larval development and a sex-ratio distortion in Litomosoides sigmodontis caused by Wolbachia-depleted microfilariae and localization of a filarial nematode phosphate permease up-regulated during Wolbachia depletion
Arumugam, Sridhar (2009-04-07)The thesis investigates the endosymbiosis between Wolbachia bacteria and their host filarial nematodes. The rodent filaria Litomosoides sigmodontis harbour Wolbachia endosymbionts and the pattern of ...