E-Dissertationen: Auflistung E-Dissertationen nach Autor "Schneider, Tanja"
Anzeige der Dokumente 1-16 von 16
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Analyse der Zellwand-Architektur von Staphylococcus aureus Stämmen mit reduzierter Vancomycin-Empfindlichkeit
(2022-02-02)<em>Staphylococcus aureus</em> ist ein opportunistischer Erreger, der vor allem bei stationärer Patientenbehandlung zu teilweise schwerwiegenden Infektionen führt. Im Fall von multiresistenten Vertretern von <em>S. aureus</em> ... -
Antibiotic-induced cellular effects in Wolbachia: Insights from cell wall biosynthesis inhibitors and corallopyronin A
(2025-10-24)(noch nicht zugänglich / not yet accessible) -
Biochemical and Structural Characterization of β-Hydroxylases in Non-Ribosomal Peptide Biosynthesis
(2022-02-02)Hydroxylases are essential in the biosynthesis of natural products by functionalization of building blocks, which derive from primary metabolism. They provide hydrophily for specific interactions or enable further ... -
Detection of bacterial contaminations in platelet concentrates using Raman spectroscopy and flow cytometry
(2023-10-17)Transfusion of contaminated platelet concentrates (PC) implicates the risk of systemic infections leading to fatal sepsis, due to ideal growth conditions for bacteria during storage. Despite that, microbiological testing ... -
Dissecting the cellular effects of antimicrobial agents: The spatio-temporal impact of peptidoglycan synthesis inhibiting antibiotics in Staphylococcus aureus and mechanism of action elucidation of epilancin A37
(2024-07-03)The increasing threat of antibiotic resistance requires innovation in antibiotic research and development. However, the knowledge of how antimicrobial agents kill bacteria is still limited, even for clinically relevant ... -
The elucidation of the modes of action of moenomycin and corallorazine A
(2024-07-16)Antimicrobial resistance poses a serious threat to public health worldwide. To overcome this global problem and ensure the supply of effective antibiotics for the therapy of infectious diseases in the future requires to ... -
The glmS ribozyme is an antibacterial target: Mode of action analysis, investigation of potential metabolite analogs and characterization of glmS ribozyme variants of human pathogens
(2018-05-22)Bacteria increasingly develop resistances to the known antibiotics, this threatens human health. Thus, novel antibiotics are urgently needed. The currently used antibiotics mainly target five bacterial processes and are ... -
Expanding the understanding of peptidoglycan turnover in Chlamydiae: biosynthesis, degradation and recycling
(2023-03-29)The obligate intracellular chlamydiae evolved mechanisms to persist inside their host and to evade the host immune system, making them intriguing and highly successful pathogens. This work aimed to asses how these strategies ... -
Exploring the mechanisms of chlamydial cell division, peptidoglycan turnover, and persistence
(2025-04-29)(noch nicht zugänglich / not yet accessible) -
I) Characterization of LytR-CpsA-Psr enzymes and their role in Staphylococcus aureus cell wall formation
(2022-04-04)
II) Elucidating the mode of action of Cacaoidin, a novel class V lantibiotic Antibiotic resistance poses a serious threat to human health, demanding for the discovery and development of antibiotics with resistance-breaking properties. New antibiotics should be sought with the focus on novel chemistry ... -
Lipid II-binding antibiotics – differential antibiotic activities beyond sequestration of the central peptidoglycan precursor
(2023-04-28)Antibiotic resistance has reached crisis proportions and is a leading mortality factor worldwide. Despite the relevance for public health globally, the antibiotic-discovery pipeline is drying up. The reason for the steep ... -
Low Endotoxin Recovery: Wiederfindung und pyrogene Aktivität von Endotoxinen in pharmazeutischen Produkten
(2021-08-06)Eine zuverlässige Überwachung bakterieller Kontaminationen ist entscheidend für die Herstellung und Sicherheit biopharmazeutischer Produkte. Die mikrobielle Sicherheit wird in der Regel (zusätzlich zu Sterilitätstests und ... -
Mechanism of Action Analyses of Cell Wall Synthesis Inhibitors and Lipophilic Derivatives with Enhanced Antibiotic Activity
(2025-05-21)(noch nicht zugänglich / not yet accessible) -
Natural product chemistry and biosynthetic studies of secondary metabolites from the marine-derived fungus Stachylidium sp.
(2016-03-22)The fungal kingdom has made considerable contributions to the production of peptide secondary metabolites, many of them with therapeutic potential, e.g. the immunosuppressant cyclosporine and the antifungal echinocandins. ... -
Untersuchungen zur Bestimmung der minimalen selektiven Konzentration von Antibiotika und Schwermetallen
(2025-06-12)Die vorliegende Arbeit besteht aus zwei Komponenten. Der erste Teil dieser Arbeit war im interdisziplinären Verbundprojekt HyReKA verortet und bot Unterstützung der Feldarbeit durch Laborwerte. Denn zum Zeitpunkt der Arbeit ... -
Untersuchungen zur Wirkungsweise von Cervimycin
(2023-06-22)Durch die Zunahme von Antibiotika-Resistenzen werden neue antimikrobiell wirksame Substanzen dringend gebraucht, laut WHO unter anderem gegen Staphylococcus aureus. Diese Arbeit gliedert sich in zwei Teile, zum einen die ...
