E-Dissertationen: Browsing E-Dissertationen by Subject "P-glycoprotein"
Now showing items 1-3 of 3
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Funktionelle Untersuchungen des ABC-Transporters P-Glykoprotein
Müller, Henrik (2007)Genaue Erkenntnisse über die Zahl und die Spezifität der Bindungsstellen von P-Glykoprotein liegen bis zum heutigen Tag nicht vor. Für die Entwicklung von potenten Modulatoren, die eine möglichst selektive Inhibition der ... -
Investigations of Combined Strategies to reverse P-glycoprotein- and BCRP-mediated Multidrug Resistance in Human Ovarian Cancer Cells and Xenograft Tumors
Jekerle, Veronika (2006)<b>Purpose</b>: The ATP-binding cassette (ABC) transporters P-glycoprotein (Pgp) and BCRP are implicated in the multidrug resistance (MDR) of many tumors. Pgp-mediated MDR can be functionally inhibited using small molecule ... -
Structural conformational analysis of molecular dynamics of a P-glycoprotein homology model and generated intermediate structures
Hafner, Melanie Salome (2019-10-02)The major reason for failure of chemotherapy in cancer is multidrug resistance. A mechanism by which human cancers develop multi-drug resistance is over expression of certain ATP-binding cassette (ABC) transporters. ...