E-Dissertationen: Search
Now showing items 51-60 of 285
The role of guanine nucleotide exchange factors in the regulation of immune cell signaling
(2009-07-08)
The ARF GEF cytohesin-1 was originally identified as β2-integrin binding protein, and was shown to play an important role in the control of integrin-dependent immune cell migration and adhesion via activating the small ...
Der Einfluss des Geschlechtshormons Östrogen auf die elektromechanische Kopplung des Herzens
(2009-07-21)
Im Rahmen dieser Arbeit wurde der Einfluss des Geschlechtshormons Östrogen auf die elektromechanische Kopplung von Herzmuskelzellen bestimmt. Ziel dieser Studie war es, Kenntnisse über die genauen physiologischen Abläufe ...
Identification of Quantitative Trait Loci in Alcoholism
(2009-07-20)
The aim of the present study was the identification of chromosomal loci that contribute to the development and manifestation of behaviours related alcohol drinking and alcohol withdrawal. For this purpose, a serial behavioural ...
Study of Human-Specific Microglial Receptor Siglec-11 and Generation of Transgenic Mice Expressing Human Siglec-11
(2009-07-07)
Siglec-11 is a recently identified human-specific CD33-related Siglec expressed on microglia. The full-length cDNA of Siglec-11 encodes 5 extracellular Ig-like domains, a single pass transmembrane domain, and a cytosolic ...
Cell-cell adhesion mediated by mobile receptor-ligand pairs: a biomimetic study
(2009-05-07)
This thesis aims at a quantitative understanding of the physical processes in cell-cell adhesion caused by mobile cell adhesion molecules. To unequivocally separate physical processes from active biological cell response, ...
Marine-derived fungi: a source for structurally new and bioactive secondary metabolites
(2009-05-25)
The marine habitat has been proven to be a rich source for both macro- and microorganisms that produce novel and often highly bioactive natural products. Hence, the investigation of the secondary metabolite spectrum of ...
Charakterisierung der Induktion von CD8 T Zell-Immunität durch sinusoidale Endothelzellen der Leber
(2009-06-19)
Die Leber spielt eine entscheidende Rolle bei der Induktion der peripheren Toleranz. Hierbei sind die sinusoidalen Endothelzellen der Leber (LSEC) von großer Bedeutung, welche mit CD8 T Zellen interagieren und in diesen T ...
Identification and characterization of novel keratin associated proteins using a genetic interaction screening system
(2009-07-21)
Keratins are an integral and important constituent of the epithelial cytoskeleton and protect epithelial cells against stress. In addition to their well-established function as cytoskeletal scaffolds in epithelia, recent ...
Lineage Selection and Enhanced Tissue Integration of Functional and Cryopreservable Human Embryonic Stem Cell-Derived Neurons
(2009-05-13)
In this study, a human Doublecortin (DCX) promoter-based lineage selection strategy is presented for the generation of purified human embryonic stem (hES) cell-derived immature neurons. Stable transfection of long-term ...
Biochemical and functional analysis of innexin2-containing gap junction channels during organogenesis in Drosophila
(2009-05-13)
Gap junctions channels serve as mediators for direct cell-to cell communication between cells of different tissues and organs by the exchange of small metabolites and signalling molecules. They are formed by analogous ...