E-Dissertationen: Suche
Anzeige der Dokumente 51-60 von 583
The role of endocannabinoid system in brain aging
(2012-07-23)
Endocannabinoid system has recently been shown to play a role in brain aging. Mice lacking cannabinoid CB1 receptors (CB1 receptor knockout, Cnr1-/- mice) show signs of accelerated aging specific to the brain and cognitive ...
Die Hydroxylierung von Ectoin und Derivaten durch die Hydroxylase EctD aus Halomonas elongata
(2012-05-08)
Kompatible Solute, von halophilen Mikroorganismen intrazellulär akkumulierte Substanzen zur Aufrechterhaltung des Turgors, sind in den letzten Jahren stark ins Interesse der biotechnologischen Forschung gerückt. Neben ihrer ...
Neural crest development in a human embryonic stem cell-based model system
(2012-09-03)
The neural crest is a transient embryonic cell population with outstanding characteristics. After their delamination from the closing neural tube, neural crest cells migrate extensively throughout the body and differentiate ......
Bei der Neuralleiste handelt es sich um eine transiente, embryonale Zellpopulation mit außergewöhnlichen Eigenschaften. Nach Verlassen des sich schließenden Neuralrohres migrieren die Neuralleistenzellen durch den Körper ......
Bei der Neuralleiste handelt es sich um eine transiente, embryonale Zellpopulation mit außergewöhnlichen Eigenschaften. Nach Verlassen des sich schließenden Neuralrohres migrieren die Neuralleistenzellen durch den Körper ......
Identification of genetic factors involved in the regulation of stress
(2012-08-29)
In this QTL mapping study, several genetic regions were linked to anxiety- and depression-related behavior in the mouse. Furthermore, some previously identified QTL linked to these behavioral traits were verified in the ...
Novel lantibiotics from microbial genomes
(2012-07-19)
The discovery of antibiotics was one of the most important milestones in medicine and in the fight against infectious disease. Today, more than 80% of anti-infective drugs are natural or semi-synthetic compounds. Rapidly ...
Computational Analysis of Structure-Activity Relationships: From Prediction to Visualization Methods
(2012-07-18)
Understanding how structural modifications affect the biological activity of small molecules is one of the central themes in medicinal chemistry. By no means is structure-activity relationship (SAR) analysis a priori ...
Revealing the Mechanism of Thiopeptide Antibiotics at Atomistic Resolution: Implications for Rational Drug Design
(2012-07-18)
For decades drug design has primarily focused on small molecules that bind to well-formed tight binding pockets, such as the catalytic centers of enzymes. Recently, there is increasing interest to design compounds that ...
A Mathematical Model of the Potassium Homeostasis in Saccharomyces cerevisiae
(2012-07-20)
Without potassium, all living cells will die; it has to be present in sufficient amounts for the proper function of most cell types. Disturbances in potassium levels in animal cells result in potentially fatal conditions ...
Characterization of Parathyroid Hormone Receptor 1 in Periodontal Ligament Cells
(2012-07-13)
In addition to the classic catabolic effects, it is now widely accepted that parathyroid hormone (PTH) exerts anabolic effects on bone, when administered intermittently. As a result of the regenerative characteristic, ......
Mining the Medical and Patent Literature to Support Healthcare and Pharmacovigilance
(2012-07-18)
Recent advancements in healthcare practices and the increasing use of information technology in the medical domain has lead to the rapid generation of free-text data in forms of scientific articles, e-health records, ...