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Structural and functional characterization of human coagulation factor XIII
(2020-06-02)
The formation of a fibrin clot in blood plasma is a two-step event which involves formation of a “primary clot” comprising of fibrin polymers by from fibrin monomers under the action of thrombin and subsequently the ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Geometric and topological recursion and invariants of the moduli space of curves
(2021-10-29)
A thread common to many problems of enumeration of surfaces is the idea that complicated cases can be recovered from simpler ones through a recursive procedure. Solving the problem for the simplest topologies and expressing ...
Analyse der Zellwand-Architektur von Staphylococcus aureus Stämmen mit reduzierter Vancomycin-Empfindlichkeit
(2022-02-02)
Staphylococcus aureus ist ein opportunistischer Erreger, der vor allem bei stationärer Patientenbehandlung zu teilweise schwerwiegenden Infektionen führt. Im Fall von multiresistenten Vertretern von S. aureus wird oftmals ......
Analyse des Lon Einflusses auf die Hitze-induzierte Aggregation mitochondrialer Proteine und auf die Bildung von Aggregatablagerungen
(2020-07-13)
Die mitochondriale Matrix Protease Lon ist ein essentieller Bestandteil des mitochondrialen Protein Qualitätskontroll-Systems. Der Verlust von Lon führt zu einer erhöhten Apoptoserate und embryonaler Letalität im Mausmodell. ...
A geometric approach to the embedding calculus knot invariants
(2020-10-09)
In this thesis we consider two homotopy theoretic approaches to the study of spaces of knots: the theory of finite type invariants of Vassiliev and the embedding calculus of Goodwillie and Weiss, and address connections ...
Structural aspects of the plasmalemmal Amyloid Precursor Protein cluster
(2021-11-12)
Alzheimer’s Disease (AD) is a major socio-economic threat to health care systems and society in general. Involvement of the amyloid-beta peptide (Aβ) and its parent, the amyloid precursor protein (APP), in AD seemed obvious ...
Quantenchemische Untersuchung der elektronischen Eigenschaften von Ferriten
(2021-06-21)
Die vorliegende Arbeit befasst sich mit der theoretischen Untersuchung der optischen und elektronischen Eigenschaften von Spinell-Ferriten MFe2O4 mit M = Mg, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn und ......
On Discrete and Geometric Firefighting
(2021-08-19)
Wildfires ravaging forests around the globe cost lives, homes and billions in damages every year, which motivates the study of effective firefighting. In the area of theoretical computer science, several different models ......
Identification of low-valent iron-porphyrins: Electronic structure and reactivity towards CO2 reduction
(2022-01-25)
The need to close the carbon cycle becomes urgent as concentration of CO2 in the earth atmosphere increases exponentially. Electrochemically-mediated conversion of CO2 into biofuels is a possible ...