E-Dissertationen: Suche
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Regulation des Cochaperons BAG3 durch Phosphorylierung und Dephosphorylierung
(2020-01-07)
Die Zelle ist die kleinste Organisationseinheit, aus der alle Organismen aufgebaut sind. Sie ist auf ein Gleichgewicht der Proteinausstattung, die Proteostase, angewiesen. Auch das Cytoskelett ist essentiell für die Zelle, ...
Analysis of two selected cell wall proteins and one lncRNA involved in desiccation tolerance of the resurrection plant Craterostigma plantagineum
(2020-01-07)
Water deficit is a severe stress negatively affecting plant growth and productivity. Extreme dehydration, termed desiccation, will lead to substantial water loss from cells and eventually results in less than 10% RWC ...
Chemoinformatics-Driven Approaches for Kinase Drug Discovery
(2020-01-07)
Given their importance for the majority of cell physiology processes, protein kinases are among the most extensively studied protein targets in drug discovery. Inappropriate regulation of their basal levels results in ...
Unraveling TRIM71-mediated RNA regulatory mechanisms during developmental and oncogenic processes
(2020-05-18)
A dysregulation in the tight control of cell proliferation and differentiation severely affects developmental processes, and can lead to oncogenic transformation in the adult organism. The stem cell-specific protein TRIM71 ...
Characterization of cellular functions of the deubiquitinating enzyme OTUD4
(2020-08-10)
Post-translational modification of proteins with ubiquitin influences myriad of cellular processes by affecting protein stability, degradation, localization and protein-protein interactions. Ubiquitin gets transferred to ...
Talentierte symbiontische Naturstoffproduzenten als Quelle neuer Wirkstoffe
(2020-03-03)
Zunehmende Resistenzen und gleichzeitig sinkende Zahlen neu zugelassener Antibiotika lassen den Bedarf an neuen antibiotischen Wirkstoffen steigen. Aber auch in anderen medizinischen Bereichen wie z. B. der Onkologie ist ...
Design, Entwicklung und Herstellung modifizierter gastroretentiver schwimmender Systeme auf Basis von schmelzextrudierten hohlen Zylindermatrices
(2020-04-15)
Die Entwicklung gastroretentiver Arzneiformen ist komplex, da neben der kontrollierten Freisetzung des Wirkstoffs zusätzlich die Verlängerung der Verweilzeit im Magen gewährleistet werden muss. Hierfür werden meist hydrophile ...
Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients
(2020-03-19)
The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order ...
Characterisation of the unknown gene and the corresponding protein At3g29075 in Arabidopsis thaliana
(2020-04-01)
Phospholipases D (PLDs) are involved in different plant stress responses, exclusively to abiotic stresses like cold, salinity, and drought. The PLD enzymes catalyse the hydrolysis of membrane phospholipids into phosphatidic ......
Analyzing the impact of astrocyte-oligodendrocyte gap junction coupling on neuronal activity in the thalamus
(2020-04-01)
Glia is now recognized as a key element in brain metabolism. In the thalamus, astrocytes and oligodendrocytes are coupled via gap junction channels and form extensive panglial networks. Interestingly and in contrast to ...