E-Dissertationen: Suche
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Toward a precision medicine in Alzheimer’s Disease: blood phenomic fingerprint for diagnostic and therapeutic developments
(2020-05-05)
There is an unmet clinical need to identify reliable blood biomarkers for Alzheimer’s Disease (AD) that can be used for diagnostics and therapeutic purposes.
The complex nature of AD, single-readout approaches ......
The complex nature of AD, single-readout approaches ......
Influence of cyclic mechanical strain on tissues of the central nervous system
(2020-12-17)
Although the brain is the softest tissue of the human body, cells embedded in the brain are responding to physiological mechanical cues. Tissue homeostasis is, therefore, not only dependent on chemical cues (e.g. growth ...
The Acyl-ACP Thioesterase FatM from Lotus japonicus is involved in lipid transfer during Arbuscular Mycorrhiza Symbiosis
(2020-01-27)
Arbuscular mycorrhiza colonization of roots is an ancient symbiosis that presumably was involved in the conquest of the land by early plants. Its main benefit for plants is the increased access to soil mineral nutrients ...
The Phenomenon of Functional Retention of Incorporated Chloroplasts in Sea Slugs (Sacoglossa, Heterobranchia, Mollusca) and Evolutionary Adaptations: Aspects of Photobiology, Cell Biology, Ecology and Behavior
(2020-01-30)
The phenomenon of retention of functional chloroplasts from their food algae in sacoglossan sea slugs - also called kleptoplasty - is a challenge for research, still leaving many questions unsolved, e. g. concerning ......
Proteomic identification of posttranslational modifications: cAMP-induced changes of phosphorylation and investigation of novel approaches detecting posttranslational modifications at lysine and arginine residues
(2020-04-22)
Cyclic adenosine monophosphate (cAMP) is an important second messenger which can be generated in response to signals binding to stimulatory G-protein coupled receptors. Inside the cell, protein kinase A is a well-known ...
Impact of UGT1A polymorphisms on inflammation and fibrogenesis in a humanized transgenic mouse model
(2020-07-07)
Fibrogenesis represents a highly dynamic scarring response of the liver resulting from different causes of hepatic injury. A key process capable of activating a broad array of profibrogenic pathways is oxidative stress. ...
Stereoselektive Polyolsynthese zur Untersuchung von Wasserstoffbrückenbindungen mittels IR-Spektroskopie
(2020-12-11)
Um die anomalen Eigenschaften des Wassers gänzlich zu verstehen, ist die intensive Untersuchung von Wasserstoffbrücken erforderlich. IR-spektroskopische Messungen vernetzter Flüssigkeiten liefern dabei eine Fülle an ...
Microevolutionary processes and taxonomic investigations of the Atacama Desert flora
(2020-12-22)
Plant evolutionary processes in the hyper arid Atacama Desert of northern Chile are here investigated using our species/species complexes as case studies based on the following research questions:
(1) Are populations ......
(1) Are populations ......
Development of workflows for metabarcoding of mass-samples: A case study on Diptera
(2020-02-14)
The main goal was developing a workflow for comprehensive biodiversity monitoring using a DNA Barcoding approach. As one of the major insect groups in the Palearctic the diverse order of Diptera served as an experimental ...
Development of oligomer-specific antibodies against tau protein and testing of therapeutic potential in a cell model of tau pathology
(2020-04-15)
Tau, a microtubule associated protein, forms abnormal aggregates in many neurodegenerative diseases such as Alzheimer disease (AD). There is an urgent need for disease-modifying therapies of AD and related tauopathies. ......