E-Dissertationen: Search
Now showing items 81-90 of 119
Polymer-mediated solubility enhancement and supersaturation stabilization using various hydroxypropyl cellulose grades within amorphous solid dispersions
(2024-05-14)
Solubility enhancement in combination with supersaturation stabilization of poorly soluble drugs is a well-established concept to enhance oral bioavailability. One promising formulation principle to overcome low solubility ...
Funktion des Eisen-Schwefelflavoproteins DsrL im dissimilatorischen Schwefelstoffwechsel
(2024-05-21)
Das FeS-Cluster enthaltende Flavoprotein DsrL besitzt NAD(P)H-Oxidoreduktase-Aktivität und dient als Elektronendonor oder -akzeptor für die von DsrAB katalysierte Reaktion während der dissimilatorischen Sulfat/Sulfit-Reduktion ...
The yeast prion domain Sup35 NM models features of human neurodegenerative diseases in vivo
(2024-05-21)
In neurodegenerative diseases, such as prion diseases and Alzheimer’s disease, disease- associated proteins misfold and form amyloid deposits that progressively invade the CNS, leading to severe neurodegeneration. Accumulating ...
Charakterisierung der NLRP3-abhängigen und -unabhängigen IL-1β-Freisetzung in Makrophagen
(2024-05-22)
Interleukin (IL)-1β ist ein primärer Botenstoff, der für die Vermittlung von Entzündungen verantwortlich ist und damit eine zentrale Rolle bei zahlreichen Krankheiten spielt. Bisher wird die IL-1β-Freisetzung allerdings ......
G protein-coupled receptors mobilize intracellular calcium via the Gs-βγ-PLCβ module
(2024-05-22)
(noch nicht zugänglich / not yet accessible)
Data Science with Foundation Models: An Evidence-Based, Comprehensive Project Methodology
(2024-05-23)
In the past decades, the interest in data science has surged across sectors and industries. Data science has been impacted by a series of paradigm shifts, such as the emergence of big data, cloud computing or the demand ...
Alzheimer’s and inflammation: exploring the interplay between immune cells in the peripheral immune system and the central nervous system through single-cell RNA-seq
(2024-05-23)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the most common cause of dementia and the sixth leading cause of death globally (Haque & Levey, 2019; World Health Organization, 2017). Increases ...
The Effect of Ivy Leaf Dry Extract EA 575® on the Signalling of Adenosine Receptor A2B
(2024-05-23)
Ivy leaf dry extract EA 575® is used to alleviate the symptoms associated with chronic inflammatory bronchial diseases and acute inflammation of the respiratory tract accompanied by coughing. Its mechanism of ...
Order-Theoretic Combination Techniques and the Electronic Schrödinger Equation
(2024-05-22)
Most standard constructions of the combination technique [M. Griebel et al., Iterative Methods in Linear Algebra, Elsevier, North Holland, p. 263] manipulate families of functions organised by downward-closed subsets of ......
Deep Learning for Causal Inference and Latent Dynamical Modeling in Biomedical Research
(2024-06-03)
Biological systems are ubiquitous, encompassing complex molecular networks governing single-cell organisms to expansive ecosystems profoundly impacting our planet's environment. In biology, the adoption of a systems approach ...