E-Dissertationen: Search
Now showing items 381-390 of 632
Selection of an aptamer and development of a genetic device to control mRNA stability in response to light
(2022-02-09)
Artificial autocatalytic RNA molecules, so-called aptazymes, are utilized as genetic devices to study and influence biological processes. These genetic devices consist of the autocatalytic RNA part, the ribozyme, and a ...
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
(2021-01-19)
Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ...
Perception and memories in the fly brain
(2022-02-03)
The brain is an extremely complex organ that controls thoughts, memories, motor skills and every process that is required to maintain our body alive and healthy. Although this is common knowledge, the mechanisms by which ...
The role of GPR111 in adipose tissue
(2021-05-21)
Due to obesity pandemic and limited therapeutic approaches, novel targets of pharmaceutical treatments are urgently needed. AT as a very important metabolic organ is an attractive target for combating obesity and obesity ......
Identification of Intracellular Protein Binding Partners of Cisplatin and Their Role in Acquired and Intrinsic Resistance
(2021-03-18)
Cisplatin is a widely used drug in treatment of various solid tumors, amongst others ovarian cancer. However, whereas acquired resistance significantly limits therapy success, some tumors such as colorectal cancer are ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
(2020-11-16)
Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies into measuring the Higgs CP-state in H → ττ decays at ATLAS
(2020-07-16)
Since the discovery of the Higgs boson in 2012, experimental particle physics made large efforts to measure all properties of the new particle to characterise all its properties as precisely as possible.
So far, all ...
So far, all ...
Ionic liquids as novel reaction media for the chemical synthesis of peptides
(2016-12-09)
To seek the best solvent in which the peptide can dissolve is usually a serious challenge in peptide chemical synthesis. Ionic liquids, which are liquid below 100 °C, or even at room temperature, showed an outstanding ...
Aptamers for targeted activation of T cell-mediated immunity
(2016-09-19)
An attractive way of preventing or curing infections and diseases is to mobilize patient’s own defense mechanisms, the immune system. Treatments following this approach are commonly known as immunotherapies. The development ...