E-Dissertationen: Search
Now showing items 621-630 of 632
Immune modifying effect of drug free PLGA nanoparticles on the course of experimental autoimmune neuritis (EAN)
(2024-03-15)
Experimental autoimmune neuritis (EAN) animal model mimics the human Guillain-Barre syndrome (GBS), an autoimmune disease of demyelination and inflammation of peripheral nerves. Despite advancement in clinical management ...
Converting the elusive G protein-coupled adenosine A3 receptor into a highly-stable, well-characterized receptor model for structural studies
(2023-03-06)
The G protein-coupled adenosine A3 receptor (A3AR) is widely expressed in the human body, with the highest expression levels found in lung and liver. The receptor is involved in a number of pathological processes, e.g., ...
Development of Molecular Chimeras Targeting the NLRP3 Inflammasome and HDAC6
(2024-03-28)
(noch nicht zugänglich / not yet accessible)
Investigations on structure and biosynthesis of ribosomal peptide natural products involved in a tripartite mutualistic interaction
(2024-04-16)
(noch nicht zugänglich / not yet accessible)
Climate-Mining interactions and the effects on rural resilience: Perspectives from southwestern Ghana
(2024-02-20)
Exploitation of natural resources including minerals contribute immensely toward development at different scales across West Africa. Mining is a prominent land-use practice within the region owing to the deposition of ...
Engagement of NKT cells during cross-priming enhances the CD8+ T cell response via GATA3 and IL-4/TNFα
(2022-04-21)
(noch nicht zugänglich / not yet accessible)
Neuroanatomie und Funktionsmorphologie Peripherer Rezeptorneurone mit Direkten Projektionen in das Protocerebrum des Insektengehirns
(2023-04-20)
Zur Wahrnehmung unterschiedlicher thermischer Reize hat sich bei Insekten eine Reihe von Thermorezeptoren entwickelt. Der pyrophile („feuerliebend“) „Australische Feuerkäfer“ (Merimna atrata) besitzt paarige Infrarot-(IR)-Organe ......
Polymer-mediated solubility enhancement and supersaturation stabilization using various hydroxypropyl cellulose grades within amorphous solid dispersions
(2024-05-14)
Solubility enhancement in combination with supersaturation stabilization of poorly soluble drugs is a well-established concept to enhance oral bioavailability. One promising formulation principle to overcome low solubility ...
The yeast prion domain Sup35 NM models features of human neurodegenerative diseases in vivo
(2024-05-21)
In neurodegenerative diseases, such as prion diseases and Alzheimer’s disease, disease- associated proteins misfold and form amyloid deposits that progressively invade the CNS, leading to severe neurodegeneration. Accumulating ...
Charakterisierung der NLRP3-abhängigen und -unabhängigen IL-1β-Freisetzung in Makrophagen
(2024-05-22)
Interleukin (IL)-1β ist ein primärer Botenstoff, der für die Vermittlung von Entzündungen verantwortlich ist und damit eine zentrale Rolle bei zahlreichen Krankheiten spielt. Bisher wird die IL-1β-Freisetzung allerdings ......