E-Dissertationen: Search
Now showing items 591-600 of 627
Identification and pharmacological characterization of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) and -4 (NPP4) inhibitors
(2022-07-29)
Ectonucleotidases are enzymes involved in different physiological functions and mainly in the regulation of purinergic signaling; in fact, they regulate the duration of purinergic receptor activation by catalyzing the ...
Medicinal chemistry and molecular pharmacology of orphan human Mas-related G protein-coupled receptors X2 and X4 (MRGPRX2 and MRGPRX4)
(2021-10-19)
The MRGPRX protein subfamily comprise rhodopsin-like orphan GPCRs, whose endogenous agonists have not been identified yet. They are exclusively expressed in primates, including humans. All Mas-related GPCRs (MRGPRs) were ...
Enhanced skin permeation of small molecules via retention of enhancer substances in matrix-type transdermal patches
(2022-08-29)
A long-standing approach to improve the transdermal drug permeation is to use chemical penetration enhancers. Those substances reduce the barrier properties of the skin, especially of the stratum corneum, and facilitate ...
Die humane RNA-Helikase DDX19: Identifizierung ihres Kernimportsignals und Analyse ihrer Rolle beim Export von mRNA
(2023-01-20)
Der mRNP-Export durch DDX19
Der nukleare Export von mRNPs (messenger-Ribonukleoproteine) wird in menschlichen Zellen durch die RNA-Helikase DDX19, zusammen mit dem Nukleoporin NUP214 und dem Exportfaktor Gle1 ......
The human RNA helicase DDX19 : identification of its nuclear import signal and analysis of its role in mRNA export
The mRNP export by DDX19
Nuclear export of mRNPs (messenger ribonucleoproteins) ......
Der nukleare Export von mRNPs (messenger-Ribonukleoproteine) wird in menschlichen Zellen durch die RNA-Helikase DDX19, zusammen mit dem Nukleoporin NUP214 und dem Exportfaktor Gle1 ......
The human RNA helicase DDX19 : identification of its nuclear import signal and analysis of its role in mRNA export
The mRNP export by DDX19
Nuclear export of mRNPs (messenger ribonucleoproteins) ......
Lipid II-binding antibiotics – differential antibiotic activities beyond sequestration of the central peptidoglycan precursor
(2023-04-28)
(noch nicht zugänglich / not yet accessible)
Time Filter Assisted Deep Learning to Predict Air Pollution
(2023-07-13)
Exposure to ground-level ozone harms human health as well as the entire ecosystem, so accurate prediction of ozone exposure is of particular importance. Machine learning (ML), and deep learning (DL) in particular, has ...
Integrated Terrestrial Simulations over Europe: Groundwater-Atmosphere Feedbacks with Altered Water Tables Including the Effect of Recent Droughts
(2023-08-08)
The groundwater flow is an essential part of the terrestrial system encompassing the atmosphere, land surface, and subsurface. In past research, there was usually no focus on water in the subsurface because climate models ...
Elucidation of multinumerous centrosomes and their impact on migration in dendritic cells
(2023)
Centrosomes act as major microtubule organizing center (MTOC) in most animal cells and are well known for their role in building up the mitotic spindle during cell division. Core structure of the centrosome are two tubulus ...
Molecular determinants of prostate cancer aggressiveness: an analysis of the interconnection between biomarkers,disease drivers and resistance mechanisms towardsnovel diagnostic, theranostic and therapeutic approaches
(2023-06-21)
The diagnosis of prostate cancer (PCa) is still mainly based on morphological criteria but is supported by biomarker analysis, which is currently mainly performed on an immunohistochemical basis. Newly developed techniques ......
Climate and land use change impacts on floods in the Mono River basin of Togo and Benin
(2023-06-22)
Floods are prominent in West Africa and are expected to exacerbate due to global changes, including climate change, land use change, as well as industrial and infrastructure development. It is important to evaluate in ...