E-Dissertationen: Suche
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The Role of TRIM71 in Male Germ Cell Development
(2020-09-02)
Germ cells are the key to continuation of life as they are the unique cell lineage capable to transfer the complete genetic information to the next generation. Both, infertility and testicular cancers are usually originating ......
Simultaneous identification of nucleotide-modified aptamers with different properties by multiplexed click-SELEX
(2020-06-18)
Voltage-gated sodium channels (VGSC) are important key regulators in excitable tissue that initiate and propagate the action potential in specifically excitable tissue such as brain nerves or muscle. In order to understand ...
Design & generation of an efficient E. coli cell-factory for the overproduction of the compatible solutes ectoine & hydroxyectoine
(2020-07-01)
The compatible solutes ectoine and hydroxyectoine are produced by halophilic or halotolerant bacteria in order to balance and adapt to osmotic alterations in their habitat. Besides this, the potent ability of these compounds ...
Selection of an aptamer and development of a genetic device to control mRNA stability in response to light
(2022-02-09)
Artificial autocatalytic RNA molecules, so-called aptazymes, are utilized as genetic devices to study and influence biological processes. These genetic devices consist of the autocatalytic RNA part, the ribozyme, and a ...
Analyse von periplasmatischen Schwefeltransferasen aus Allochromatium vinosum
(2021-07-19)
Die ersten Schritte der Schwefeloxidation in Allochromatium vinosum finden im Periplasma statt, wo reduzierte Schwefelverbindungen oxidiert und in diesem Zuge Schwefelkugeln aufgebaut werden. Es ist denkbar, dass ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Simulation of Bone Remodeling Process around Dental Implant During the Healing Period
(2021-07-05)
This interdisciplinary thesis deals with the numerical investigation of bone remodeling around dental implants during the healing period with regard to biomechanical aspects. The aim of the study was to develop algorithms ...
Influence of the St. John's Wort Extract Ze117 on the Lipidome of PBMC and on the Lateral Diffusion of ß1-Adrenergic Receptors in C6 Cells
(2021-03-18)
Stress causes pathological changes in the signal transduction of neurotransmitter systems, which can lead to depression. Signaling relies not only on receptor-ligand interactions and subsequent regulatory processes, but ...
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
(2020-11-16)
Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Eosinophil Extracellular DNA Trap Cell Death (EETosis) occurs as a life-cycle stage-specific response to filariae
(2020-06-25)
Filarial nematodes represent a great burden of human morbidity causing diseases like onchocerciasis and lymphatic filariasis. The lack of a vaccination and a short-term therapy with a macrofilaricidal effect hampers the ......