E-Dissertationen: Search
Now showing items 11-20 of 21
Investigation of Multipotent Neural Progenitor Cell to Oligodendrocyte Differentiation including the Transcriptional Activator Protein Pur-alpha by Quantitative Proteomics
(2019-02-26)
Oligodendrocytes are neuroglial cells, localized in the white matter of the central nervous system. They develop from neural stem cells (NSCs), which produce, among others, migrating and proliferating oligodendrocyte ...
Functional roles of the chemokine CCL17 in skin and brain immunity
(2019-02-04)
The chemokines CCL17 and CCL22 represent ligands of CCR4 and are mainly produced by dendritic cells (DCs) and macrophages (Mφs) in the immune system. CCL17 was found to promote various inflammatory and allergic diseases, ......
Funktionen des Chemokins CCL17 im Immunsystem der Haut und des Gehirns
Die Chemokine CCL17 und CCL22 sind Liganden von CCR4 und werden hauptsächlich von dendritischen Zellen (DCs) und Makrophagen ......
Funktionen des Chemokins CCL17 im Immunsystem der Haut und des Gehirns
Die Chemokine CCL17 und CCL22 sind Liganden von CCR4 und werden hauptsächlich von dendritischen Zellen (DCs) und Makrophagen ......
Untersuchung von adenosinergen Regulatorproteinen der zirkadianen Rhythmik im Gehirn der Ratte und deren Veränderungen durch Schlafentzug und chronische Koffeineinnahme
(2019-03-07)
Der Neuromodulator Adenosin stellt eine der bedeutendsten schlafregulierenden Substanzen für die Steuerung des Einschlafprozesses dar. Es konnte gezeigt werden, dass Adenosin seine schlafinduzierende Wirkung vorwiegend ...
Charakterisierung des CPEB3 Ribozyms: Studien zur Aufklärung des Mechanismus eines humanen Ribozyms
(2019-03-27)
Kurze RNA Stränge mit enzymatischer Aktivität sind als Ribozyme bekannt. Das HDV-ähnliche CPEB3 Ribozym ist eine wenig erforschte selbstspaltende RNA. Es existiert in einer einzelnen hochkonservierten Kopie in der Sequenz ...
Effects of Mitochondrial Nucleases on mtDNA Degradation
(2019-01-11)
Mitochondria are unique to have a multicopy genome, resulting in a substantially different fate of damaged DNA molecules in comparison to nuclear DNA. Damaged DNA usually represents only a small fraction of total mitochondrial ...
Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry
(2019-06-21)
Compound promiscuity offers both opportunities and perils for medicinal chemistry and drug discovery. On the one hand, it is well-established that compounds elicit their therapeutic potential by engaging with multiple ...
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)
Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for the synthesis of ......
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...
Microglial Activation in Alzheimer's Disease
(2019-06-05)
Alzheimer's disease (AD) is the most prevalent type of dementia and characterized by the deposition of extracellular amyloid-beta (Aβ) and tau hyper-phosphorylation. Over the past decade, neuroinflammation has emerged as ...