E-Dissertationen: Search
Now showing items 1121-1130 of 1158
Charakterisierung des mitochondrialen Stresssensors Pink1 während der Mitophagie
(2024-03-08)
Die vorliegende Arbeit beschäftigt sich mit der zentralen Frage der Regulation von Pink1, einer Parkinson-assoziierten Kinase, die in gesunden Zellen als mitochondrialer Stresssensor agiert. Als Folge auf eine starke ...
Structural and Functional Characterization of Human Transcription-regulating Kinases
(2024-03-12)
(noch nicht zugänglich / not yet accessible)
Biochemical and structural studies of NOD-like receptors and their inhibition by small molecule inhibitors
(2023-03-07)
NOD-like receptors (NLRs) are innate immune sensors that can form inflammasomes driving pyroptosis. NLRP3 is the best studied member of the NLRs to date, and its dysregulation has been linked to human diseases relevant to ...
Converting the elusive G protein-coupled adenosine A3 receptor into a highly-stable, well-characterized receptor model for structural studies
(2023-03-06)
The G protein-coupled adenosine A3 receptor (A3AR) is widely expressed in the human body, with the highest expression levels found in lung and liver. The receptor is involved in a number of pathological processes, e.g., ...
Analysis of reprogramming-associated alterations using an isogenic human stem cell system
(2022-03-04)
Human induced pluripotent stem cells (iPSCs) could provide a valuable tool for the production of specific somatic cell types for disease modeling or cell replacement. Considering the molecular complexity of the reprogramming ...
Identification of Genetic Risk Variants for the Development of Gastric Adenocarcinoma
(2023-03-07)
Gastric cancer (GC) is a clinically heterogeneous and one of the most common malignant tumour entities affecting the human gastrointestinal tract with a multifactorial aetiology. Beside environmental risk factors, also ...
Invasion biology of amphibians and reptiles: From observations to predictive spatial models
(2024-04-04)
(noch nicht zugänglich / not yet accessible)
Molecular Characterization of Quality Control Factors at the Protein Entry Gate of Mitochondria
(2024-04-04)
(noch nicht zugänglich / not yet accessible)
Establishing blood-based classifiers for decentralized and privacy-preserving disease prediction
(2024-04-08)
Big data is increasingly being generated across all sectors of medicine and high-dimensional omics data have been shown to be a powerful data space for AI applications that can assist in primary and differential diagnostics, ...
Identification of alpha-synuclein and ataxin-3 expression modifying compounds
(2024-02-16)
(noch nicht zugänglich / not yet accessible)