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The mesoscale organization of Syntaxin 1A and SNAP25 at the plasma membrane
(2023-03-09)
The plasma membrane is a highly crowded place consisting of a plethora of proteins and lipids, which show a high degree of micropatterning. Most proteins are not homogeneously distributed but concentrated in clusters. ...
Novel lipoate-binding proteins and their role in sulfur oxidation
(2024-04-29)
The global sulfur cycle is a highly complex network of interconnected processes that involve the conversion of organic and inorganic sulfur compounds across multiple redox states. Driven by prokaryotes through the oxidation, ......
Einfluss von Kohlenstoffdioxid auf mikrobielle Zellmembranen beim Modified Atmosphere Packaging und Charakterisierung capnotoleranter Mikroorganismen
(2024-04-29)
Diese Arbeit liefert wichtige Hinweise auf CO2-induzierte Veränderungen der Zellmembran bei unterschiedlichen Mikroorganismen. In vorhergehenden Forschungsarbeiten konnte bislang nicht eindeutig geklärt werden, ...
Single-cell dissections of Rosette-to-Lumen stage embryoids - and the Glucose-6-phosphate isomerase-induced arthritis model
(2024-05-13)
Single-cell omics (SCO), particularly single-cell RNA-sequencing (scRNA-seq), are widely used to describe dynamic biological and pathophysiological processes. This thesis explores the utility of SCO in characterizing dynamic ......
Evaluation of Striatin as a novel Microtubule Modulator
(2023-04-13)
The dynamics of the cell cycle and cell division are governed by tubulin polymers, i. e. microtubules (MTs). Defects of MT assembly or disassembly lead to pathogenic cellular conditions, negatively affecting cell viability, ......
GPR183 controls spatial organization and survival of hepatic conventional dendritic cells within hepatic portal regions via M-CSF and Gas6
(2023-04-19)
G protein-coupled receptor 183 (GPR183) recognizes 7α,25-dihydroxycholesterol (7α,25-OHC) and exerts chemotactic action upon recognition. Recent studies have shown that GPR183 is highly expressed in T, B and dendritic cells ...
Neuroanatomie und Funktionsmorphologie Peripherer Rezeptorneurone mit Direkten Projektionen in das Protocerebrum des Insektengehirns
(2023-04-20)
Zur Wahrnehmung unterschiedlicher thermischer Reize hat sich bei Insekten eine Reihe von Thermorezeptoren entwickelt. Der pyrophile („feuerliebend“) „Australische Feuerkäfer“ (Merimna atrata) besitzt paarige Infrarot-(IR)-Organe ......
Ectopic expression of transcription factors to overcome the lineage barrier between embryonic stem cells and trophoblast stem cells in mouse and human
(2023-04-19)
The placenta is a transient organ that exhibits various essential functions during pregnancy that allow for proper development of the embryo. Placenta and embryo originate from the first lineage separation in mammalian ...
The Immune Memory Response and Metabolic Requirements of Human Gamma Delta T Cells
(2024-05-14)
γδ T cells are unconventional T cells that can mediate pro-inflammatory, cytotoxic, phagocytotic and professional antigen presenting properties. Sharing the features of both adaptive and innate immunity, γδ T cells also ...