E-Dissertationen: Search
Now showing items 51-60 of 109
Biochemical and structural characterization of the NLRP3 inflammasome
(2020-02-13)
The innate immune system utilizes inflammasome proteins to recognize danger signals and to fight invading pathogens. To date, the most studied inflammasome protein is NLRP3 - a multidomain protein, composed of a N-terminal ...
Characterization of Ceramide synthase 2 dysfunctions caused by targeted mutations in transgenic mice
(2020-02-10)
Ceramide species are the precursor of sphingolipids, which serve as structural components of biological membranes or are bioactive molecules. In mammals, ceramides are synthesised by a family of ceramide synthases (CerS) ......
Neuronal and Circuit Architecture Underlying Feeding Behavior in Drosophila
(2021-06-28)
Feeding is elemental for survival and one of the most common activities of animals. Little is known about the organization of neuronal circuits controlling feeding behavior in the cen-tral nervous system. This study maps, ...
High fat diet modulates conventional dendritic cell development through Interferon regulatory factor 8
(2022-07-21)
During obesity-associated inflammation, myeloid cells play an essential role in initiating and maintaining inflammation during diet-induced obesity. In recent years, more evidence has linked conventional dendritic cell ...
Electric Imaging in Weakly Electric Fish and Biomimetic Devices
(2022-08-03)
The nocturnal and weakly electric fish Gnathonemus petersii inspects its murky habitats by self-generated electric signals; an adaption called active electrolocation, enabled by the fish's active electric sense. Animals, ......
Electric Imaging – Aktive Elektroortung in schwach elektrischen Fischen und bionischen Sensoren
Der nachtaktive und schwach elektrische Fisch Gnathonemus petersii besitzt einen aktiven elektrischen ......
Electric Imaging – Aktive Elektroortung in schwach elektrischen Fischen und bionischen Sensoren
Der nachtaktive und schwach elektrische Fisch Gnathonemus petersii besitzt einen aktiven elektrischen ......
Synthesis and structure-activity relationships of CD39 and CD73 inhibitors
(2022-08-13)
Ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1 or CD39) is a member of the membrane-bound ecto-nucleotidase family, which catalyzes the extracellular hydrolysis of pro-inflammatory ATP and pro-thrombotic ADP ......
Targeting nucleic acid receptors to improve filarial vaccination in the Litomosoides sigmodontis model
(2022-10-27)
Lymphatic filariasis and onchocerciasis (river blindness) are human filarial diseases, which put a high socio-economic burden on endemic countries. Until now no vaccination is available, which could greatly aid elimination ......
Hippocampal network and inhibitory neuron dysfunction in age and disease
(2021-10-25)
Aging and Alzheimer’s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. Mechanistically, it has been suggested that remodeling of inhibitory ......
Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...