E-Dissertationen: Search
Now showing items 81-90 of 103
Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients
(2020-03-19)
The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order ...
Hippocampal network and inhibitory neuron dysfunction in age and disease
(2021-10-25)
Aging and Alzheimer’s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. Mechanistically, it has been suggested that remodeling of inhibitory ......
Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)
Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......