E-Dissertationen: Search
Now showing items 4041-4050 of 4118
Polymer-mediated solubility enhancement and supersaturation stabilization using various hydroxypropyl cellulose grades within amorphous solid dispersions
(2024-05-14)
Solubility enhancement in combination with supersaturation stabilization of poorly soluble drugs is a well-established concept to enhance oral bioavailability. One promising formulation principle to overcome low solubility ...
Human iPSC-derived in vitro models of the peripheral nervous system for cellular pain and somatosensation research
(2022-01-07)
The term 'somatosensation' summarizes the sensation of touch, body position, temperature and pain experienced by animals or humans. Peripheral sensory neurons can be classified according to their primary sensation as ...
Funktion des Eisen-Schwefelflavoproteins DsrL im dissimilatorischen Schwefelstoffwechsel
(2024-05-21)
Das FeS-Cluster enthaltende Flavoprotein DsrL besitzt NAD(P)H-Oxidoreduktase-Aktivität und dient als Elektronendonor oder -akzeptor für die von DsrAB katalysierte Reaktion während der dissimilatorischen Sulfat/Sulfit-Reduktion ...
The yeast prion domain Sup35 NM models features of human neurodegenerative diseases in vivo
(2024-05-21)
In neurodegenerative diseases, such as prion diseases and Alzheimer’s disease, disease- associated proteins misfold and form amyloid deposits that progressively invade the CNS, leading to severe neurodegeneration. Accumulating ...
Charakterisierung der NLRP3-abhängigen und -unabhängigen IL-1β-Freisetzung in Makrophagen
(2024-05-22)
Interleukin (IL)-1β ist ein primärer Botenstoff, der für die Vermittlung von Entzündungen verantwortlich ist und damit eine zentrale Rolle bei zahlreichen Krankheiten spielt. Bisher wird die IL-1β-Freisetzung allerdings ......
G protein-coupled receptors mobilize intracellular calcium via the Gs-βγ-PLCβ module
(2024-05-22)
(noch nicht zugänglich / not yet accessible)
Data Science with Foundation Models: An Evidence-Based, Comprehensive Project Methodology
(2024-05-23)
In the past decades, the interest in data science has surged across sectors and industries. Data science has been impacted by a series of paradigm shifts, such as the emergence of big data, cloud computing or the demand ...
Alzheimer’s and inflammation: exploring the interplay between immune cells in the peripheral immune system and the central nervous system through single-cell RNA-seq
(2024-05-23)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the most common cause of dementia and the sixth leading cause of death globally (Haque & Levey, 2019; World Health Organization, 2017). Increases ...
On growth patterns and mechanisms in Mediterranean-alpine shrubs
(2023-05-22)
(noch nicht zugänglich / not yet accessible)