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The Immune Memory Response and Metabolic Requirements of Human Gamma Delta T Cells
(2024-05-14)
γδ T cells are unconventional T cells that can mediate pro-inflammatory, cytotoxic, phagocytotic and professional antigen presenting properties. Sharing the features of both adaptive and innate immunity, γδ T cells also ...
Human iPSC-derived in vitro models of the peripheral nervous system for cellular pain and somatosensation research
(2022-01-07)
The term 'somatosensation' summarizes the sensation of touch, body position, temperature and pain experienced by animals or humans. Peripheral sensory neurons can be classified according to their primary sensation as ...
Activation Mechanisms of RIG-I
(2020-11-02)
(noch nicht zugänglich / not yet accessible)
Mechanistic investigations of organocatalytic and gold-catalyzed reactions and synthetic approach towards a chiral bifunctional catalyst
(2023-05-09)
The first part of this thesis focuses on the mechanistic studies of an intermolecular cyclization reaction between an α,β-unsaturated aldehyde and an electron deficient primary alkyne to a cyclopentene carbaldehyde. Based ......
Theoretical Studies of Nuclear Magnetic Resonance Chemical Shifts
(2024-05-21)
Nuclear magnetic resonance (NMR) spectroscopy is among the most important analytical methods for the determination of the chemical structure of matter. Its versatile applicability leads to the necessity of reliable ...
Holistic Video Understanding: Spatio-Temporal Modeling and Efficiency
(2024-05-21)
Video understanding, a specialized area within computer vision, focuses on classifying human actions in video clips. The field has seen remarkable advancements, particularly with the introduction of 3D convolutional neural ...
Funktion des Eisen-Schwefelflavoproteins DsrL im dissimilatorischen Schwefelstoffwechsel
(2024-05-21)
Das FeS-Cluster enthaltende Flavoprotein DsrL besitzt NAD(P)H-Oxidoreduktase-Aktivität und dient als Elektronendonor oder -akzeptor für die von DsrAB katalysierte Reaktion während der dissimilatorischen Sulfat/Sulfit-Reduktion ...
The yeast prion domain Sup35 NM models features of human neurodegenerative diseases in vivo
(2024-05-21)
In neurodegenerative diseases, such as prion diseases and Alzheimer’s disease, disease- associated proteins misfold and form amyloid deposits that progressively invade the CNS, leading to severe neurodegeneration. Accumulating ...
Charakterisierung der NLRP3-abhängigen und -unabhängigen IL-1β-Freisetzung in Makrophagen
(2024-05-22)
Interleukin (IL)-1β ist ein primärer Botenstoff, der für die Vermittlung von Entzündungen verantwortlich ist und damit eine zentrale Rolle bei zahlreichen Krankheiten spielt. Bisher wird die IL-1β-Freisetzung allerdings ......