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Deciphering Effector Protein Functions of Ustilago maydis involved in gall formation
(2024-06-14)
(noch nicht zugänglich / not yet accessible)
Search for solar axions using a 7-GridPix IAXO prototype detector at CAST
(2024-06-17)
The Standard Model of particle physics describes three out of four known fundamental forces of nature very successfully. However, open questions remain. One of these, the 'strong CP problem', asks why the neutron has no ......
Analysis of the physiological response of perivascular adipose tissue during cold exposure
(2023-02-22)
Aortic valve disease (AVD) is common for people over 65 and its severity increases with age. Aortic aneurysm (AA) is the tenth cause of death for men above 55. Its prevalence was estimated to be up to 8.9% for men and up ...
The aqueous corrosion of borosilicate glasses studied in operando by in situ fluid-cell Raman spectroscopy
(2023-01-30)
Die Eigenschaften von Gläsern hängen vor allem von deren chemischen Zusammensetzung ab und sind aufgrund der großen Zusammensetzungsvielfalt sehr variabel, was eine Vielzahl von Anwendungsmöglichkeiten eröffnet.
Assays and ligands for underexplored membrane proteins with potential as future drug targets
(2023-05-30)
In this study, pharmacological assays were established and employed to identify and characterize compounds regarding their potential as tool compounds, lead structures, and drug candidates for three underexplored potential ...
Charakterisierung der Neddylierung von Cofilin1: Einfluss auf die neuronale Entwicklung
(2022-12-22)
Nachdem lange davon ausgegangen wurde, dass die posttranslationale Modifikation durch Nedd8 nur bestimmte Culline und den Zellzyklus reguliert, sind in den vergangenen Jahren weitere neddylierte Proteine gefunden worden, ...
Mass spectrometric analysis of short-lived intermediates and ancient fossils
(2021-06-14)
The first part of this thesis focuses on mechanistic studies of two L-proline catalyzed reactions with electrospray ionization mass spectrometry. The second part describes mass spectrometric analyses of fossils, dinosaur ...
Untersuchung der molekularen Mechanismen einer Thrombozytenaktivierung durch Karzinomzellen und die Rolle des Tumormarkers MACC1 in diesem Prozess
(2023-05-31)
Die Interaktion der Tumorzellen mit Thrombozyten und die damit einhergehende Aktivierung ist ein Schlüsselfaktor der Tumormetastasierung. Die molekularen Mechanismen einer Thrombozytenaktivierung durch Tumore können sehr ...
Optimisation of the Data Reduction for the Belle II Pixel Detector and Development of a new Track Finding Algorithm using the Belle II Vertex Detector
(2023-05-15)
The Belle II experiment, located at the SuperKEKB collider in Tsukuba, Japan, is recording data at world record luminosities in order to provide world-leading results in the field of particle physics in the future. To ...
Cellular mechanoresponse to extracellular matrix shear strain and stiffness studied in a cell culture model of breast gland development
(2023-05-12)
Mechanobiological regulation is a crucial element for tissue development and homeostasis. Dysregulation of the normal mechanobiological microenvironment of cells is linked to disease and negatively affects cancer patients' ...